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Topo I-IN-1 (Compound 14d) is a potent Topo I inhibitor that exhibits antitumor activity, DNA intercalative capability, and can induce cell apoptosis.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $1,520 | 10-14 weeks | |
50 mg | $1,980 | 10-14 weeks | |
100 mg | $2,500 | 10-14 weeks |
Description | Topo I-IN-1 (Compound 14d) is a potent Topo I inhibitor that exhibits antitumor activity, DNA intercalative capability, and can induce cell apoptosis. |
In vitro | Topo I-IN-1 (Compound 14d) exhibits significant antiproliferative effects on human cancer cells, including A549, HCT116, MCF7, and SK-MEL-28, while showing lower toxicity to normal rat kidney epithelial cells (NRK). In vitro cytotoxicity assays determined IC50 values of 2.33 ± 1.52 μM (A549), 2.85 ± 0.83 μM (HCT116), 26.23 ± 2.48 μM (MCF7), 3.86 ± 0.33 μM (SK-MEL-28), and 29.99 ± 0.95 μM (NRK), indicating a potent and selective toxicity profile. At lower doses (0-4 μM), Topo I-IN-1 induces dose-dependent apoptotic activity in A549 cells, marked by morphological changes, ROS generation, and inhibition of cell migration, further elucidating its anticancer mechanism [1]. |
Molecular Weight | 408.25 |
Formula | C20H14BrN3O2 |
Storage | Shipping with blue ice. |
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