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Tos-PEG12-Tos
Catalog No. T18848Cas No. 1456708-45-4
Tos-PEG12-Tos is a PEG-based linker for PROTACs, facilitating the conjugation of two essential ligands [Tosyl(Tos)] critical for the formation of PROTAC molecules, and enabling selective protein degradation via the ubiquitin-proteasome system within cells.
Tos-PEG12-Tos
Catalog No. T18848Cas No. 1456708-45-4
Tos-PEG12-Tos is a PEG-based linker for PROTACs, facilitating the conjugation of two essential ligands [Tosyl(Tos)] critical for the formation of PROTAC molecules, and enabling selective protein degradation via the ubiquitin-proteasome system within cells.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 mg | Inquiry | Backorder | |
| 500 mg | Inquiry | Backorder |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Tos-PEG12-Tos is a PEG-based linker for PROTACs, facilitating the conjugation of two essential ligands [Tosyl(Tos)] critical for the formation of PROTAC molecules, and enabling selective protein degradation via the ubiquitin-proteasome system within cells. |
| In vitro | PROTACs are compounds that use a linker to connect two distinct ligands: one binding to an E3 ubiquitin ligase and the other to the target protein. They leverage the intracellular ubiquitin-proteasome system to selectively degrade target proteins [1]. |
| Molecular Weight | 855.02 |
| Formula | C38H62O17S2 |
| Cas No. | 1456708-45-4 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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