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Tos-PEG3

Name: Tos-PEG3
Brand: TargetMol
SKU: T17129
Price: 53 USD
Availability: InStock
Rating: 4.5 (1 reviews)

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Catalog No. T17129Cas No. 77544-68-4

Tos-PEG3, a PEG-based PROTAC linker, is suitable for synthesizing PROTACs and 3'-aminooxy oligonucleotide solid supports[1].

Tos-PEG3

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Catalog No. T17129Cas No. 77544-68-4

Tos-PEG3, a PEG-based PROTAC linker, is suitable for synthesizing PROTACs and 3'-aminooxy oligonucleotide solid supports[1].

Pack Size	Price	Availability	Quantity
100 mg	Inquiry	7-10 days
500 mg	Inquiry	7-10 days

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Product Introduction

Bioactivity

Description	Tos-PEG3, a PEG-based PROTAC linker, is suitable for synthesizing PROTACs and 3'-aminooxy oligonucleotide solid supports[1].
In vitro	PROTACs consist of two distinct ligands connected by a linker: one ligand binds to an E3 ubiquitin ligase, and the other to the target protein. They utilize the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Chemical Properties

Molecular Weight	304.36
Formula	C₁₃H₂₀O₆S
Cas No.	77544-68-4
Relative Density.	1.234 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 100 mg/mL (328.56 mM), Sonication and heating are recommended.

H2O: 10 mg/mL (32.86 mM), Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2856 mL	16.4279 mL	32.8558 mL	164.2791 mL
5 mM	0.6571 mL	3.2856 mL	6.5712 mL	32.8558 mL
10 mM	0.3286 mL	1.6428 mL	3.2856 mL	16.4279 mL
20 mM	0.1643 mL	0.8214 mL	1.6428 mL	8.2140 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0657 mL	0.3286 mL	0.6571 mL	3.2856 mL
100 mM	0.0329 mL	0.1643 mL	0.3286 mL	1.6428 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Tos-PEG-3Tos PEG3Tos-PEG3TosPEG3