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TPT-260 Dihydrochloride

🥰Excellent
Catalog No. T1856Cas No. 2076-91-7
Alias TPU-260 Dihydrochloride, TPT260 2HCl, NSC55712

TPT-260 Dihydrochloride (NSC55712) is a thiophene thiourea derivative with molecule weight 260.00 in free base form.

TPT-260 Dihydrochloride

TPT-260 Dihydrochloride

🥰Excellent
Purity: 97.93%
Catalog No. T1856Alias TPU-260 Dihydrochloride, TPT260 2HCl, NSC55712Cas No. 2076-91-7
TPT-260 Dihydrochloride (NSC55712) is a thiophene thiourea derivative with molecule weight 260.00 in free base form.
Pack SizePriceAvailabilityQuantity
2 mg$35In Stock
5 mg$55In Stock
10 mg$92In Stock
25 mg$176In Stock
50 mg$281In Stock
100 mg$412In Stock
200 mg$586In Stock
1 mL x 10 mM (in DMSO)$55In Stock
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Purity:97.93%
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Product Introduction

Bioactivity
Description
TPT-260 Dihydrochloride (NSC55712) is a thiophene thiourea derivative with molecule weight 260.00 in free base form.
Kinase Assay
Lyophilized Cdc42 protein is reconstituted to 5 mg/mL in a buffer consisting of 50 mM Tris, 0.5 mM MgCl2, 50 mM NaCl, 3% (wt/vol) sucrose, and 0.6% dextran. The stock solution is then diluted to 1 μM in 5 mM phosphate buffer, pH 7.4. Into a quartz cuvettete containing Cdc42 solution, aliquots of ZCL278 are added and incubated for 5 min before each fluorescent measurement. The excitation wavelength is 275 nm, and the fluorescence of tryptophan at 350 nm is measured after each addition. The titration curve is fitted using the equimolar specific binding model in GraphPad, and the Kd is calculated[1].
AliasTPU-260 Dihydrochloride, TPT260 2HCl, NSC55712
Chemical Properties
Molecular Weight333.32
FormulaC8H14Cl2N4S3
Cas No.2076-91-7
SmilesCl.Cl.NC(=N)SCc1ccc(CSC(N)=N)s1
Relative Density.1.59g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 9 mg/mL (27 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.0001 mL15.0006 mL30.0012 mL150.0060 mL
5 mM0.6000 mL3.0001 mL6.0002 mL30.0012 mL
10 mM0.3000 mL1.5001 mL3.0001 mL15.0006 mL
20 mM0.1500 mL0.7500 mL1.5001 mL7.5003 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
%Tween 80
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Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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