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Triprolidine
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Catalog No. T60514Cas No. 486-12-4
Triprolidine is an orally active antagonist of H1R. Triprolidine has spinal cord motor and sensory block effects. Triprolidine can be used in allergic rhinitis research[1] [2] [3].
Triprolidine
😃Good
Catalog No. T60514Cas No. 486-12-4
Triprolidine is an orally active antagonist of H1R. Triprolidine has spinal cord motor and sensory block effects. Triprolidine can be used in allergic rhinitis research[1] [2] [3].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $1,520 | 1-2 weeks | |
| 50 mg | $1,980 | 1-2 weeks | |
| 100 mg | $2,500 | 1-2 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Triprolidine is an orally active antagonist of H1R. Triprolidine has spinal cord motor and sensory block effects. Triprolidine can be used in allergic rhinitis research[1] [2] [3]. |
| In vitro | Triprolidine, which matures human dendritic cells, acts as an antagonist to histamine H1 and reduces the expression of CD45 [1]. |
| In vivo | Triprolidine, administered intrathecally at doses ranging from 292.81 to 1467.20 μg/kg, induces a dose-dependent spinal block affecting both motor and sensory functions in male Sprague-Dawley rats [2]. This effect was observed in the specified animal model weighing between 300-350 g. |
| Molecular Weight | 278.39 |
| Formula | C19H22N2 |
| Cas No. | 486-12-4 |
Storage & Solubility Information
| Storage | Shipping with blue ice. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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