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TSHR antagonist S37a
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Catalog No. T13217Cas No. 2143452-20-2
TSHR antagonist S37a is a selective antagonist of thyrotropin receptor (TSHR), with potential for the treatment of Graves' orbitopathy.
TSHR antagonist S37a
😃Good
Catalog No. T13217Cas No. 2143452-20-2
TSHR antagonist S37a is a selective antagonist of thyrotropin receptor (TSHR), with potential for the treatment of Graves' orbitopathy.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $476 | 6-8 weeks | |
| 25 mg | $1,530 | 6-8 weeks | |
| 50 mg | $1,990 | 6-8 weeks | |
| 100 mg | $2,980 | 6-8 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | TSHR antagonist S37a is a selective antagonist of thyrotropin receptor (TSHR), with potential for the treatment of Graves' orbitopathy. |
| In vitro | In HEK293 cells, TSHR antagonist S37a is an inhibitor of TSHR(IC50s of 40 μM and approximately 20 μM for mTSHR and hTSHR, respectively). TSHR antagonist S37a also activation by monoclonal TSAb M22 (human), KSAb1 (murine), and the allosteric small-molecule agonist C2. |
| In vivo | In GO patients' sera, TSHR antagonist S37a inhibits cyclic adenosine monophosphate formation by oligoclonal TSAb, which are highly enriched. |
| Molecular Weight | 460.57 |
| Formula | C25H20N2O3S2 |
| Cas No. | 2143452-20-2 |
| Relative Density. | 1.54 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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