UCB-J is a radioligand for the synaptic vesicle protein 2A (SV2A), utilized in positron emission tomography (PET)[4].

UCB-J demonstrates a significant unbound fraction (0.46 ± 0.02) and undergoes moderate metabolic rates in plasma, with 39% ± 5% and 24% ± 3% of the parent compound remaining after 30 and 90 minutes, respectively[3]. This compound also exhibits substantial uptake and rapid kinetics within the monkey brain[3]. Notably, pretreatment of an animal with UCB-J (150 μg/kg, iv) results in a reduction of the whole brain Standard Uptake Value (SUV) to levels comparable to those of the centrum semiovale, thereby highlighting [18F]7's in vivo binding specificity towards SV2A[4].