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UCK2 Inhibitor-3
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Catalog No. T72696Cas No. 2376687-49-7
UCK2 Inhibitor-3 is a non-competitive inhibitor of uridine-cytidine kinase 2 (UCK2), a pivotal enzyme in the pyrimidine salvage pathway, with an IC50 value of 16.6 μM. UCK2 can partially substitute for dihydroorotate dehydrogenase (DHODH) in infected or rapidly dividing cells, aiding uridine salvage. Additionally, UCK2 Inhibitor-3 inhibits DNA polymerase eta and kappa, with IC50 values of 56 μM and 16 μM, respectively.
UCK2 Inhibitor-3
😃Good
Catalog No. T72696Cas No. 2376687-49-7
UCK2 Inhibitor-3 is a non-competitive inhibitor of uridine-cytidine kinase 2 (UCK2), a pivotal enzyme in the pyrimidine salvage pathway, with an IC50 value of 16.6 μM. UCK2 can partially substitute for dihydroorotate dehydrogenase (DHODH) in infected or rapidly dividing cells, aiding uridine salvage. Additionally, UCK2 Inhibitor-3 inhibits DNA polymerase eta and kappa, with IC50 values of 56 μM and 16 μM, respectively.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $1,520 | Backorder | |
| 50 mg | $1,980 | Backorder | |
| 100 mg | $2,500 | Backorder |
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Bioactivity
Chemical Properties
| Description | UCK2 Inhibitor-3 is a non-competitive inhibitor of uridine-cytidine kinase 2 (UCK2), a pivotal enzyme in the pyrimidine salvage pathway, with an IC50 value of 16.6 μM. UCK2 can partially substitute for dihydroorotate dehydrogenase (DHODH) in infected or rapidly dividing cells, aiding uridine salvage. Additionally, UCK2 Inhibitor-3 inhibits DNA polymerase eta and kappa, with IC50 values of 56 μM and 16 μM, respectively. |
| Molecular Weight | 474.31 |
| Formula | C19H13BrFN5O2S |
| Cas No. | 2376687-49-7 |
Storage & Solubility Information
| Storage | Shipping with blue ice. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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