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Umbellulone
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Catalog No. T13953Cas No. 546-78-1
Umbellulone is a natural product isolated from Umbellularia californica, and stimulates the TRPA1 channel in a subset of peptidergic, nociceptive neurons, activating the trigeminovascular system via this mechanism.
Umbellulone
🥰Excellent
Catalog No. T13953Cas No. 546-78-1
Umbellulone is a natural product isolated from Umbellularia californica, and stimulates the TRPA1 channel in a subset of peptidergic, nociceptive neurons, activating the trigeminovascular system via this mechanism.
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Product Introduction
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Chemical Properties
| Description | Umbellulone is a natural product isolated from Umbellularia californica, and stimulates the TRPA1 channel in a subset of peptidergic, nociceptive neurons, activating the trigeminovascular system via this mechanism. |
| In vitro | Umbellulone selectively stimulates transient receptor potential ankyrin 1-expressing HEK293 cells. |
| In vivo | In Trpa1+/+ mice, Umbellulone (50–250?nM/5ul) causes an acute nocioceptive response in a dose-dependent manner . Umbellulone (30-150 μg/kg; i.v.) increases meningeal blood flow in a dose-dependent manner. |
| Molecular Weight | 150.22 |
| Formula | C10H14O |
| Cas No. | 546-78-1 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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