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Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $885 | 1-2 weeks | |
50 mg | $1,150 | 1-2 weeks | |
100 mg | $1,950 | 1-2 weeks |
Description | UNC10217938A is a 3-deazapteridine analog, has strong oligonucleotide enhancing effects. |
In vitro | When UNC10217938A is used in the range of 5-25 μM, it can significantly enhance the induction of luciferase in HelaLuc705 cells, and it is more effective and more effective than Retro-1. Compared to a separate splice switch oligonucleotide (SSO), UNC10217938A provids a 60-fold enhancement at 10 μM and 220-fold at 20 μM, in contrast to a 11-fold enhancement for 100 μM Retro-1. UNC10217938A can substantially enhance effects of receptor targeted oligonucleotide conjugates. UNC10217938A can also enhance the effect of uncharged morpholino oligonucleotides and negatively charged oligonucleotides . Exposure of cells to UNC10217938A caused a significant reduction in the colocalization of TAMRA-oligonucleotides with the late ribosomal marker Rab7, but had little effect on the colocalization with the lysosomal marker LAMP-1. UNC10217938A causes partial release of oligonucleotide from late endosomes to the cytosol followed by nuclear accumulation. |
Molecular Weight | 456.54 |
Formula | C26H28N6O2 |
Cas No. | 1347749-97-6 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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