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Uridine-5'-O-(3-thiotriphosphate) sodium

Catalog No. T83840
Alias UTP-γ-S

Uridine-5'-O-(3-thiotriphosphate) (UTP-γ-S) is a hydrolysis-resistant UTP derivative and an agonist of the purinergic P2Y2 receptor. It effectively induces inositol phosphate formation in 1321N1 astrocytoma cells harboring the human P2Y2 receptor (EC50 = 240 nM) and stimulates chloride secretion in a dose-dependent manner in primary nasal epithelial cells from cystic fibrosis patients. Moreover, UTP-γ-S prompts vasoconstriction in isolated human coronary arteries (EC50 = 25.1 µM).

Uridine-5'-O-(3-thiotriphosphate) sodium

Uridine-5'-O-(3-thiotriphosphate) sodium

Catalog No. T83840Alias UTP-γ-S
Uridine-5'-O-(3-thiotriphosphate) (UTP-γ-S) is a hydrolysis-resistant UTP derivative and an agonist of the purinergic P2Y2 receptor. It effectively induces inositol phosphate formation in 1321N1 astrocytoma cells harboring the human P2Y2 receptor (EC50 = 240 nM) and stimulates chloride secretion in a dose-dependent manner in primary nasal epithelial cells from cystic fibrosis patients. Moreover, UTP-γ-S prompts vasoconstriction in isolated human coronary arteries (EC50 = 25.1 µM).
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Product Introduction

Bioactivity
Description
Uridine-5'-O-(3-thiotriphosphate) (UTP-γ-S) is a hydrolysis-resistant UTP derivative and an agonist of the purinergic P2Y2 receptor. It effectively induces inositol phosphate formation in 1321N1 astrocytoma cells harboring the human P2Y2 receptor (EC50 = 240 nM) and stimulates chloride secretion in a dose-dependent manner in primary nasal epithelial cells from cystic fibrosis patients. Moreover, UTP-γ-S prompts vasoconstriction in isolated human coronary arteries (EC50 = 25.1 µM).
AliasUTP-γ-S
Chemical Properties
Molecular Weight588.14
FormulaC9H11N2O14P3S.4Na
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
H2O: Soluble

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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