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USP7-IN-12

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Catalog No. T79164Cas No. 2763698-01-5

USP7-IN-12 (compound 1) is a potent, orally active Usp7 inhibitor with an IC50 of 3.67 nM, demonstrating antiproliferative activity [1].

USP7-IN-12

USP7-IN-12

😃Good
Catalog No. T79164Cas No. 2763698-01-5
USP7-IN-12 (compound 1) is a potent, orally active Usp7 inhibitor with an IC50 of 3.67 nM, demonstrating antiproliferative activity [1].
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5 mgInquiry8-10 weeks
50 mgInquiry8-10 weeks
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Product Introduction

Bioactivity
Description
USP7-IN-12 (compound 1) is a potent, orally active Usp7 inhibitor with an IC50 of 3.67 nM, demonstrating antiproliferative activity [1].
Targets&IC50
USP7:3.67 nM
In vitro
USP7-IN-12 (compound 1), following a 72-hour incubation period, exhibited antiproliferative activity, with an IC50 value of 69.5 nM against RS4;11 [1].
In vivo
USP7-IN-12 (5 mg/kg; oral) exhibited favorable pharmacokinetic properties in male SD rats: a half-life (T1/2) of 3.68 hours, time to maximum concentration (Tmax) of 3.33 hours, peak concentration (Cmax) of 330 ng/mL, and area under the curve from time zero to infinity (AUC0-inf) of 2014 hr*ng/mL [1].
Chemical Properties
Molecular Weight551.07
FormulaC29H28ClFN4O2S
Cas No.2763698-01-5
Storage & Solubility Information
StorageShipping with blue ice.

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