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UZH1a

UZH1a is a potent and selective inhibitor of METTL3, with an IC50 of 280 nM. It serves as a tool for the epitranscriptomic modulation of cellular processes, exhibits antitumor activity, and functions as a chemical probe for the study of METTL3[1].

Catalog No. T37448Cas No. 2813577-78-3

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UZH1a

Catalog No. T37448Cas No. 2813577-78-3

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Pack Size	Price	Availability	Quantity
5 mg	$946	Backorder

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Product Introduction

Bioactivity

Description

In vitro

UZH1a (2.5-160 μM; 72 h) inhibits the growth of MOLM-13, HEK293T, and U2Os cells, with IC50s of 11 μM, 67 μM, and 87 μM, respectively[1].UZH1a (2.5-100 μM; 16 h) reduces m6A methylation level in mRNA from MOLM-13 cells in a dose-dependent manner (IC50=4.6 μM)[1].UZH1a (40 μM; 16 h) reduces m6A methylation level in mRNA from MOLM-13, HEK293T, and U2Os cells[1].UZH1a (20 μM; 16 h) increases apoptosis and leads to cell cycle arrest in MOLM-13 cells[1].

Chemical Properties

Molecular Weight	558.71
Formula	C₃₂H₄₂N₆O₃
Cas No.	2813577-78-3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 80 mg/mL (143.19 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7898 mL	8.9492 mL	17.8984 mL	89.4919 mL
5 mM	0.3580 mL	1.7898 mL	3.5797 mL	17.8984 mL
10 mM	0.1790 mL	0.8949 mL	1.7898 mL	8.9492 mL
20 mM	0.0895 mL	0.4475 mL	0.8949 mL	4.4746 mL
50 mM	0.0358 mL	0.1790 mL	0.3580 mL	1.7898 mL
100 mM	0.0179 mL	0.0895 mL	0.1790 mL	0.8949 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

UZH-1aUZH1a