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Vanoxerine

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Catalog No. T23501Cas No. 67469-69-6

Vanoxerine is an antagonist of dopamine transporter (Ki: 16.9nM).

Vanoxerine
Other Forms of Vanoxerine:

Vanoxerine

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Catalog No. T23501Cas No. 67469-69-6
Vanoxerine is an antagonist of dopamine transporter (Ki: 16.9nM).
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Product Introduction

Bioactivity
Description
Vanoxerine is an antagonist of dopamine transporter (Ki: 16.9nM).
Targets&IC50
Dopamine reuptake:1 nM (Ki)
In vitro
As an antagonist of DAT, vanoxerine is developed for treatment of Parkinson's disease and depression but has no effect on these diseases. Vanoxerine is also found to have desirable cardiac antiarrhythmic properties. It is a blocker of cardiac hERG (IC50:0.84nM). It also blocks the ICa,L and hNav1.5 channel (IC50: 320nM and 830nM, respectively). Vanoxerine does not significantly prolong Purkinje fiber APD60 and APD90 and has no significant effect on QT or TDR.
Chemical Properties
Molecular Weight450.56
FormulaC28H32F2N2O
Cas No.67469-69-6
Relative Density.1.135 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: Soluble

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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Keywords

Vanoxerine
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