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Vanoxerine

Catalog No. T23501Cas No. 67469-69-6

Vanoxerine is an antagonist of dopamine transporter (Ki: 16.9nM).

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Pack Size	Price	Availability	Quantity
25 mg	$1,520	Backorder

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Product Introduction

Bioactivity

Description

Vanoxerine is an antagonist of dopamine transporter (Ki: 16.9nM).

In vitro

As an antagonist of DAT, vanoxerine is developed for treatment of Parkinson's disease and depression but has no effect on these diseases. Vanoxerine is also found to have desirable cardiac antiarrhythmic properties. It is a blocker of cardiac hERG (IC50:0.84nM). It also blocks the ICa,L and hNav1.5 channel (IC50: 320nM and 830nM, respectively). Vanoxerine does not significantly prolong Purkinje fiber APD60 and APD90 and has no significant effect on QT or TDR.

Chemical Properties

Molecular Weight	450.56
Formula	C28H32F2N2O
Cas No.	67469-69-6

Storage & Solubility Information

Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year
Solubility Information	DMSO: Soluble

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

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