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Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $970 | 1-2 weeks |
Description | Venadaparib hydrochloride (IDX-1197) is a potent and selective PARP inhibitor exhibiting significant anticancer properties, particularly effective in solid tumor research. |
Targets&IC50 | PARP2:1 nM (IC50), PARP1:1.4 nM (IC50) |
In vitro | Venadaparib (example 143; 6-10 days) effectively inhibits the growth of MDA-MB-436 and Capan-1 pancreatic cancer cells, with IC50 values of ≤5nM and 50nM[2], respectively. |
In vivo | In the germline BRCA1-mutated ovarian cancer patient-derived xenograft (PDX) model, oral administration of Venadaparib (IDX-1197) significantly inhibits PAR (>90%) in tumor tissues for up to 24 hours post-dosing and exhibits dose-dependent, potent tumor growth inhibition, surpassing that of the Olaparib treatment group[1]. |
Alias | IDX-1197 hydrochloride |
Molecular Weight | 442.92 |
Formula | C23H24ClFN4O2 |
Cas No. | 1681020-60-9 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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