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VH032-PEG5-C6-Cl

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Catalog No. T17996Cas No. 1799506-06-1
Alias HaloPROTAC 2

VH032-PEG5-C6-Cl (HaloPROTAC 2) is a small molecule that includes the VH032-based VHL ligand and a 5-unit PEG linker, capable of inducing the degradation of GFP-HaloTag7 in cell-based assays[1].

VH032-PEG5-C6-Cl

VH032-PEG5-C6-Cl

😃Good
Catalog No. T17996Alias HaloPROTAC 2Cas No. 1799506-06-1
VH032-PEG5-C6-Cl (HaloPROTAC 2) is a small molecule that includes the VH032-based VHL ligand and a 5-unit PEG linker, capable of inducing the degradation of GFP-HaloTag7 in cell-based assays[1].
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Product Introduction

Bioactivity
Description
VH032-PEG5-C6-Cl (HaloPROTAC 2) is a small molecule that includes the VH032-based VHL ligand and a 5-unit PEG linker, capable of inducing the degradation of GFP-HaloTag7 in cell-based assays[1].
In vitro
Treatment with VH032-PEG5-C6-Cl for 24 hours results in approximately 70% degradation of GFP-Halotag7 at a concentration of 2.5 μM[1].
AliasHaloPROTAC 2
Chemical Properties
Molecular Weight783.41
FormulaC38H59ClN4O9S
Cas No.1799506-06-1
Relative Density.1.200 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 50 mg/mL (63.82 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.2765 mL6.3824 mL12.7647 mL63.8235 mL
5 mM0.2553 mL1.2765 mL2.5529 mL12.7647 mL
10 mM0.1276 mL0.6382 mL1.2765 mL6.3824 mL
20 mM0.0638 mL0.3191 mL0.6382 mL3.1912 mL
50 mM0.0255 mL0.1276 mL0.2553 mL1.2765 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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