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VH4127

Name: VH4127
Brand: TargetMol
SKU: TP2966
Rating: 4.5 (1 reviews)

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Catalog No. TP2966

VH4127 is a cyclic peptide designed to target low-density lipoprotein receptors (LDLR) with a KD of 18 nM for hLDLR. Incorporating non-natural amino acid residues, VH4127 binds specifically to epidermal growth factor (EGF) LDLR homologous domains in both rodents and humans.

VH4127

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Catalog No. TP2966

Pack Size	Price	Availability	Quantity
10 mg	Inquiry	Backorder
50 mg	Inquiry	Backorder

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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity

Description	VH4127 is a cyclic peptide designed to target low-density lipoprotein receptors (LDLR) with a KD of 18 nM for hLDLR. Incorporating non-natural amino acid residues, VH4127 binds specifically to epidermal growth factor (EGF) LDLR homologous domains in both rodents and humans.
Targets&IC50	hLDLR:18 nM (Kd)

Chemical Properties

Molecular Weight	1048.37
Formula	C₄₁H₇₃N₁₅O₉S₄

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc