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VU0420373

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Catalog No. T60384Cas No. 38376-29-3

VU0420373 is a potent activator of the heme sensor system (HssRS), demonstrating an EC50 of 10.7 μM and a pEC50 of 4.97. It induces heme biosynthesis and exhibits toxicity towards fermenting S. aureus [1].

VU0420373

VU0420373

😃Good
Catalog No. T60384Cas No. 38376-29-3
VU0420373 is a potent activator of the heme sensor system (HssRS), demonstrating an EC50 of 10.7 μM and a pEC50 of 4.97. It induces heme biosynthesis and exhibits toxicity towards fermenting S. aureus [1].
Pack SizePriceAvailabilityQuantity
25 mgInquiry6-8 weeks
50 mgInquiry6-8 weeks
100 mgInquiry6-8 weeks
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Product Introduction

Bioactivity
Description
VU0420373 is a potent activator of the heme sensor system (HssRS), demonstrating an EC50 of 10.7 μM and a pEC50 of 4.97. It induces heme biosynthesis and exhibits toxicity towards fermenting S. aureus [1].
In vitro
VU0420373 (compound 2e) exhibits an IC50 of >60 μM for both Newman aerobic and Newman anaerobic conditions. Additionally, at a concentration of 40 μM and over exposure periods of 2, 4, 6, and 8 hours, it can pre-adapt Staphylococcus aureus to withstand toxic levels of heme (20 μM).
Chemical Properties
Molecular Weight254.26
FormulaC15H11FN2O
Cas No.38376-29-3
Storage & Solubility Information
StorageShipping with blue ice.

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