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VU6000918
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Catalog No. T39543Cas No. 2101737-32-8
VU6000918 is a positive allosteric modulator that targets the muscarinic acetylcholine receptor subtype M4. It exhibits a half maximal effective concentration (EC50) of 19 nM for the human M4 receptor.
VU6000918
🥰Excellent
Catalog No. T39543Cas No. 2101737-32-8
VU6000918 is a positive allosteric modulator that targets the muscarinic acetylcholine receptor subtype M4. It exhibits a half maximal effective concentration (EC50) of 19 nM for the human M4 receptor.
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Product Introduction
Bioactivity
Chemical Properties
| Description | VU6000918 is a positive allosteric modulator that targets the muscarinic acetylcholine receptor subtype M4. It exhibits a half maximal effective concentration (EC50) of 19 nM for the human M4 receptor. |
| Targets&IC50 | M4 (human):19 nM (EC50) |
| In vitro | VU6000918 significantly reverses AHL by 18% at a minimal oral dosage of 0.03 mg/kg and achieves peak reversal of 74% with a 3 mg/kg dosage, yielding an in vivo plasma EC50 of 74 nM (0.66 nM unbound) according to terminal concentrations observed in study animals 1.5 hours after administering compound 17j[1]. |
| Molecular Weight | 389.42 |
| Formula | C18H17F2N5OS |
| Cas No. | 2101737-32-8 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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