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Description | VU6000918 is a positive allosteric modulator that targets the muscarinic acetylcholine receptor subtype M4. It exhibits a half maximal effective concentration (EC50) of 19 nM for the human M4 receptor. |
Targets&IC50 | M4 (human):19 nM (EC50) |
In vitro | VU6000918 significantly reverses AHL by 18% at a minimal oral dosage of 0.03 mg/kg and achieves peak reversal of 74% with a 3 mg/kg dosage, yielding an in vivo plasma EC50 of 74 nM (0.66 nM unbound) according to terminal concentrations observed in study animals 1.5 hours after administering compound 17j[1]. |
Molecular Weight | 389.42 |
Formula | C18H17F2N5OS |
Cas No. | 2101737-32-8 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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