VU6010572 is a highly potent and selective negative allosteric modulator of mGlu3, exhibiting an IC50 of 245 nM. Additionally, VU6010572 displays high central nervous system penetrance [1] [2].

VU6010572, administered intraperitoneally (i.p.) at a dosage of 3 mg/kg, demonstrates significant efficacy in CD-1 mice, exhibiting robust outcomes [1]. Moreover, when administered to rats at the same dosage and via the same route but observed after 45 minutes, VU6010572 induces enduring anxiolytic-like behavioral effects, highlighting its potent and lasting impact on anxiety-related behaviors [2].