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WD2000-012547

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Catalog No. T13333Cas No. 283172-68-9

WD2000-012547 is a selective inhibitor of poly(ADP-ribose)-polymerase (PARP-1) (pKi: 8.221).

WD2000-012547

WD2000-012547

😃Good
Catalog No. T13333Cas No. 283172-68-9
WD2000-012547 is a selective inhibitor of poly(ADP-ribose)-polymerase (PARP-1) (pKi: 8.221).
Pack SizePriceAvailabilityQuantity
25 mg$1,5206-8 weeks
50 mg$1,9806-8 weeks
100 mg$2,5006-8 weeks
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Product Introduction

Bioactivity
Description
WD2000-012547 is a selective inhibitor of poly(ADP-ribose)-polymerase (PARP-1) (pKi: 8.221).
Targets&IC50
PARP1:8.221 (pki)
In vitro
Poly(ADP-ribose) polymerase-1 (PARP-1) functions as a sensor and signal molecule for DNA damage, crucial for repairing DNA breaks from radiation and chemotherapy. Inhibition of this enzyme, exemplified by WD2000-012547—a PARP-1 inhibitor with a pKi of 8.221—shows potential to enhance cancer treatment efficacy via chemotherapy or radiotherapy.
Chemical Properties
Molecular Weight262.31
FormulaC17H14N2O
Cas No.283172-68-9
Relative Density.1.270 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords

WD2000 012547WD2000012547WD2000-012547WD-2000-012547
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