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Win 58237

Win 58237
Win 58237 is an inhibitor of cyclic nucleotide phosphodiesterase (PDE) (Ki: 170 nM for PDE V), with vasorelaxant activity.
Catalog No. T13341Cas No. 158001-76-4

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Win 58237

Catalog No. T13341Cas No. 158001-76-4

Win 58237 is an inhibitor of cyclic nucleotide phosphodiesterase (PDE) (Ki: 170 nM for PDE V), with vasorelaxant activity.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
25 mg$1,5206-8 weeks
50 mg$1,9806-8 weeks
100 mg$2,5006-8 weeks
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Product Introduction

Bioactivity
Description
Win 58237 is an inhibitor of cyclic nucleotide phosphodiesterase (PDE) (Ki: 170 nM for PDE V), with vasorelaxant activity.
Targets&IC50
PDE5:ki:170 nM
In vitro
Win 58237 is a competitive cGMP PDE V inhibitor from canine aorta(Ki : 170 nM). Win 58237 is a potent PDE V inhibitor isolated from vascular tissue (IC50 : 240 nM). It is a relatively less potent calmodulin-sensitive PDE I and cGMP-inhibitable cyclic AMP PDE III inhibitor ; but does inhibit cyclic AMP PDE IV with an IC50 value of approximately 300 nM. Win 58237 possesses vasorelaxant activity in the presence of an intact endothelium or nitric oxide.
In vivo
In vivo administration of Win 58237, at dosages ranging from 0.3 to 3.0 mg/kg intravenously, reduces mean arterial pressure in conscious spontaneously hypertensive rats, accompanied by a rise in vascular (aortic) cGMP content. Additionally, at a higher dosage of 10 mg/kg intravenously, Win 58237 elevates plasma cGMP levels from a baseline of 6.7 ± 1.0 to 31.4 ± 3.5 fmol/μL.
Chemical Properties
Molecular Weight295.34
FormulaC16H17N5O
Cas No.158001-76-4
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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