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Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $1,520 | 6-8 weeks | |
50 mg | $1,980 | 6-8 weeks | |
100 mg | $2,500 | 6-8 weeks |
Description | Win-62005 is an inhibitor of cyclic AMP phosphodiesterase III (PDE III)(Kis: 25 and 26 nM for rat heart and canine aorta). |
Targets&IC50 | PDE3:25 nM (ki), PDE3:ki:25 nM |
In vitro | Win-62005 is a competitive inhibitor of cyclic GMP-inhibitable low Km cyclic AMP phosphodiesterase (PDE III) found in rat heart and canine aorta, demonstrating high affinity with inhibition constants (Ki) of approximately 25±3 nM and 26±5 nM, respectively. Furthermore, it exhibits significant selectivity, being at least 160-fold more selective for PDE III over other phosphodiesterase (PDE) isozymes. |
In vivo | Win-62005(p.o. administration of 1 mg/kg) LVdP/dtmax is significantly increased in 30 min and remains increased for at least 6 h. |
Molecular Weight | 226.23 |
Formula | C12H10N4O |
Cas No. | 152633-54-0 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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