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WSF1-IN-1

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Catalog No. T39947Cas No. 2379577-82-7
Alias WSF1-IN-1

WSF1-IN-1 (compound 136) is an orally active inhibitor of WSF1, designed for studying WSF1-related tumors in patients with Wolfram syndrome (WS). In HepG2 parental and HepG2 WFS1 KO cell lines, WSF1-IN-1 has shown IC50 values of 0.33 μM and >27 μM, respectively.

WSF1-IN-1

WSF1-IN-1

😃Good
Catalog No. T39947Alias WSF1-IN-1Cas No. 2379577-82-7
WSF1-IN-1 (compound 136) is an orally active inhibitor of WSF1, designed for studying WSF1-related tumors in patients with Wolfram syndrome (WS). In HepG2 parental and HepG2 WFS1 KO cell lines, WSF1-IN-1 has shown IC50 values of 0.33 μM and >27 μM, respectively.
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2 mg$2355 days
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Product Introduction

Bioactivity
Description
WSF1-IN-1 (compound 136) is an orally active inhibitor of WSF1, designed for studying WSF1-related tumors in patients with Wolfram syndrome (WS). In HepG2 parental and HepG2 WFS1 KO cell lines, WSF1-IN-1 has shown IC50 values of 0.33 μM and >27 μM, respectively.
In vitro
WSF1-IN-1 (compound 136) demonstrates selective inhibition with IC50 values of >27 μM for Hek293 empty vectors and 0.03 μM for Hek293 WFS1 over-expressors. In cell viability assays, the compound shows IC50s of 0.05 μM for Colo-205 Control shRNA, >9 μM for Colo-205 WSF1 shRNA, 0.08 μM for DU4415 Control shRNA, 6.1 μM for DU4415 WSF1 shRNA, 0.26 μM for HepG2 Control shRNA, and 2.2 μM for HepG2 WSF1 shRNA, respectively[1].
In vivo
WSF1-IN-1 (compound 136, 100 mpk qd, orally, 14 days) demonstrated a tumor growth inhibition (TGI) of 106.65% in NSCLC patient-derived xenograft OD33996 nu/nu mice[1].
AliasWSF1-IN-1
Chemical Properties
Molecular Weight446.438
FormulaC20H21F3N8O
Cas No.2379577-82-7
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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Keywords

WSF-1-IN-1WSF1 IN 1WSF1IN1
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