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Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $697 | Backorder | |
10 mg | $1,120 | Backorder |
Description | YB-0158 (Wnt pathway inhibitor 2) is a powerful peptidomimetic compound that effectively targets colorectal cancer stem cells (CSCs) by disrupting the interaction between Sam68 and Src proteins. This compound acts as a reverse-turn agent, inducing apoptosis in CRC cells and displaying strong anti-cancer activities. |
In vitro | YB-0158, at concentrations of 0.2 μM and 0.5 μM over a 48-hour period, significantly enhances apoptosis in CRC cells, as evidenced by activated Caspase-3/7 detection assays[1]. Additionally, a 0.3 μM concentration of YB-0158 markedly reduces CBP recruitment at the LGR5 and MYC promoter regions of Wnt/beta-Catenin target genes in HT29 cells, compared to a DMSO control[1]. |
In vivo | YB-0158 exhibits an effective concentration (EC 50) of 1.64 μM in MC38 cells cultured in vitro. In vivo experiments utilizing C57BL/6 mice with MC38 cell-derived tumors demonstrate that YB-0158 administered intraperitoneally (IP) at a dose of 100 mg/kg does not significantly alter primary tumor size compared to saline-treated controls[2]. |
Alias | Wnt pathway inhibitor 2, YB-0158 |
Molecular Weight | 705.619 |
Formula | C32H34N7Na2O7P |
Cas No. | 1144043-83-3 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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