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ZK824859 hydrochloride (2271122-53-1 free base)

Catalog No. T13409L

ZK824859 hydrochloride is an oral available and selective inhibitor of urokinase plasminogen activator (uPA)(IC50s of 79 nM, 1580 nM and 1330 nM for human uPA, tPA, and plasmin, respectively).

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability
5 mg	$398	Backorder
10 mg	$663	Backorder
50 mg	$1,850	Backorder
100 mg	$2,905	Backorder
200 mg	Inquiry	Backorder
500 mg	Inquiry	Backorder
1 mL x 10 mM (in DMSO)	$439	Backorder

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Product Introduction

Bioactivity

Description	ZK824859 hydrochloride is an oral available and selective inhibitor of urokinase plasminogen activator (uPA)(IC50s of 79 nM, 1580 nM and 1330 nM for human uPA, tPA, and plasmin, respectively).
In vitro	ZK824859 is 5 fold less potent and has lost selectivity in mouse: uPA with IC50 of 410?nM; tPA with IC50 of 910?nM; plasmin with IC50 of 1600?nM compared to human IC50 of 79?nM, 1580?nM and 1330?nM respectively.
Alias	ZK824859 hydrochloride

Chemical Properties

Molecular Weight	464.89
Formula	C23H23ClF2N2O4
Cas No.

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 125 mg/mL (268.88 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1510 mL	10.7552 mL	21.5105 mL	107.5523 mL
5 mM	0.4302 mL	2.1510 mL	4.3021 mL	21.5105 mL
10 mM	0.2151 mL	1.0755 mL	2.1510 mL	10.7552 mL
20 mM	0.1076 mL	0.5378 mL	1.0755 mL	5.3776 mL
50 mM	0.0430 mL	0.2151 mL	0.4302 mL	2.1510 mL
100 mM	0.0215 mL	0.1076 mL	0.2151 mL	1.0755 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc