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ZSET-845

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ZSET-845

Catalog No. T13975Cas No. 324077-62-5

ZSET-845 is an enhancer of cognitive which enhances choline acetyltransferase activity in the hippocampus in the rat.

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Pack Size	Price	Availability
25 mg	$1,520	6-8 weeks
50 mg	$1,980	6-8 weeks
100 mg	$2,500	6-8 weeks

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Product Introduction

Bioactivity

Description	ZSET-845 is an enhancer of cognitive which enhances choline acetyltransferase activity in the hippocampus in the rat.
In vitro	In NB-1 cells, ZSET-845 has no inhibitory action on AChE activity and enhances choline acetyltransferase (ChAT) activity[1].
In vivo	Administered orally, ZSET-845 at doses of 0.01, 0.1, and 1 mg/kg significantly improves scopolamine-induced performance impairments. In the hippocampus, ZSET-845 enhances ChAT (choline acetyltransferase) activity, with increases noted at 112%, 113.8%, and 108.7% for the respective doses, when compared to control rats receiving a matched vehicle [1]. Moreover, ZSET-845 at concentrations of 1 or 10 mg/kg not only mitigates learning deficits in a passive avoidance task but also elevates ChAT activity within the basal forebrain, medial septum, and hippocampus. Additionally, it boosts the count of ChAT-immunoreactive cells in the medial septum among Ab-treated rats back to levels observed in vehicle-injected control rats [2].

Chemical Properties

Molecular Weight	314.38
Formula	C21H18N2O
Cas No.	324077-62-5

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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Keywords

ZSET 845ZSET-845ZSET845