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ZSET-845
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Catalog No. T13975Cas No. 324077-62-5
ZSET-845 is an enhancer of cognitive which enhances choline acetyltransferase activity in the hippocampus in the rat.
ZSET-845
😃Good
Catalog No. T13975Cas No. 324077-62-5
ZSET-845 is an enhancer of cognitive which enhances choline acetyltransferase activity in the hippocampus in the rat.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | 1.444 € | 6-8 weeks | |
| 50 mg | 1.881 € | 6-8 weeks | |
| 100 mg | 2.375 € | 6-8 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | ZSET-845 is an enhancer of cognitive which enhances choline acetyltransferase activity in the hippocampus in the rat. |
| In vitro | In NB-1 cells, ZSET-845 has no inhibitory action on AChE activity and enhances choline acetyltransferase (ChAT) activity[1]. |
| In vivo | Administered orally, ZSET-845 at doses of 0.01, 0.1, and 1 mg/kg significantly improves scopolamine-induced performance impairments. In the hippocampus, ZSET-845 enhances ChAT (choline acetyltransferase) activity, with increases noted at 112%, 113.8%, and 108.7% for the respective doses, when compared to control rats receiving a matched vehicle [1]. Moreover, ZSET-845 at concentrations of 1 or 10 mg/kg not only mitigates learning deficits in a passive avoidance task but also elevates ChAT activity within the basal forebrain, medial septum, and hippocampus. Additionally, it boosts the count of ChAT-immunoreactive cells in the medial septum among Ab-treated rats back to levels observed in vehicle-injected control rats [2]. |
| Molecular Weight | 314.38 |
| Formula | C21H18N2O |
| Cas No. | 324077-62-5 |
| Relative Density. | 1.14 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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