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Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $1,520 | 6-8 weeks | |
50 mg | $1,980 | 6-8 weeks | |
100 mg | $2,500 | 6-8 weeks |
Description | ZSET-845 is an enhancer of cognitive which enhances choline acetyltransferase activity in the hippocampus in the rat. |
In vitro | In NB-1 cells, ZSET-845 has no inhibitory action on AChE activity and enhances choline acetyltransferase (ChAT) activity[1]. |
In vivo | Administered orally, ZSET-845 at doses of 0.01, 0.1, and 1 mg/kg significantly improves scopolamine-induced performance impairments. In the hippocampus, ZSET-845 enhances ChAT (choline acetyltransferase) activity, with increases noted at 112%, 113.8%, and 108.7% for the respective doses, when compared to control rats receiving a matched vehicle [1]. Moreover, ZSET-845 at concentrations of 1 or 10 mg/kg not only mitigates learning deficits in a passive avoidance task but also elevates ChAT activity within the basal forebrain, medial septum, and hippocampus. Additionally, it boosts the count of ChAT-immunoreactive cells in the medial septum among Ab-treated rats back to levels observed in vehicle-injected control rats [2]. |
Molecular Weight | 314.38 |
Formula | C21H18N2O |
Cas No. | 324077-62-5 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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