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ZW-1226

Catalog No. T89024Cas No. 2351940-23-1

ZW-1226 is a selective MRP1 inhibitor that reduces the uptake activity of MRP1 vesicles by 65% at a concentration of 5 μM. It inhibits MRP1 in a GSH-dependent manner and exhibits considerable selectivity towards MRP1 over other primary ABC transport proteins (including P-gp, BCRP, MRP2, and MRP3).

ZW-1226

ZW-1226

Catalog No. T89024Cas No. 2351940-23-1
ZW-1226 is a selective MRP1 inhibitor that reduces the uptake activity of MRP1 vesicles by 65% at a concentration of 5 μM. It inhibits MRP1 in a GSH-dependent manner and exhibits considerable selectivity towards MRP1 over other primary ABC transport proteins (including P-gp, BCRP, MRP2, and MRP3).
Pack SizePriceAvailabilityQuantity
10 mgInquiry10-14 weeks
50 mgInquiry10-14 weeks
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Product Introduction

Bioactivity
Description
ZW-1226 is a selective MRP1 inhibitor that reduces the uptake activity of MRP1 vesicles by 65% at a concentration of 5 μM. It inhibits MRP1 in a GSH-dependent manner and exhibits considerable selectivity towards MRP1 over other primary ABC transport proteins (including P-gp, BCRP, MRP2, and MRP3).
Chemical Properties
Molecular Weight420.42
FormulaC25H16N4O3
Cas No.2351940-23-1
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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