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CDC37 Protein, Mouse, Recombinant

Catalog No. TMPY-03558
CDC37 Protein, Mouse, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 44.7 kDa and the accession number is Q61081.
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100 μg$7007-10 days
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Product Information

Biological Activity
Activity testing is in progress. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
Description
CDC37 Protein, Mouse, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 44.7 kDa and the accession number is Q61081.
Species
Mouse
Expression System
Baculovirus Insect Cells
TagTag Free
Accession NumberQ61081
Synonyms
p50Cdc37,p50,cell division cycle 37
Construction
A DNA sequence encoding the mouse CDC37 (Q61081) (Met1-Ala379) was expressed with two additional amino acids (Gly & Pro) at the N-terminus. Predicted N terminal: Gly
Protein Purity
> 85 % as determined by SDS-PAGE
Molecular Weight44.7 kDa (predicted); 46 kDa (reducing conditions)
Endotoxin< 1.0 EU/μg of the protein as determined by the LAL method.
FormulationLyophilized from a solution filtered through a 0.22 μm filter, containing 20 mM Tris, 500 mM NaCl, 10% glycerol, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution
A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage
It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
ShippingIn general, Lyophilized powders are shipping with blue ice.
Research Background
CDC37 is a protein that is expressed in proliferative zones during embryonic development and in adult tissues, consistent with a positive role in proliferation and is required for cell division in budding yeast. CDC37 is thought to play an important role in the establishment of signaling pathways controlling cell proliferation through targeting intrinsically unstable oncoprotein kinases such as Cdk-4, Raf-1, and src to the molecular chaperone Hsp90. Decreased Hsp90 expression can reduce the levels of microtubule-associated protein tau, whose overexpression may induce many diseases. CDC37 is considered as a co-chaperone that is classified as Hsp90's accessory proteins. It has been reported that suppression of Cdc37 destabilized tau, leading to its clearance, whereas cdc37 overexpression preserved tau.Cdc37 was found to co-localize with tau in neuronal cells and to physically interact with tau from human brain. Moreover, Cdc37 levels significantly increased with age.

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Please read the User Guide of Recombinant Proteins for more specific information.