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Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 μg | $192 | 20 days | |
100 μg | $1,087 | 20 days | |
500 μg | $2,442 | 20 days |
Biological Information | Fully biologically active when compared to standard. The biologically active determined by a chemotaxis bioassay using human peripheral blood lymphocytes is in a concentration range of 0.1- 10.0 ng/mL in the presence of IL-2. |
Description | CXCL10 Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 8.7 kDa and the accession number is P17515. |
Species | Mouse |
Expression System | E. coli |
Tag | Tag Free |
Accession Number | P17515 |
Synonyms | mob-1,IFI10,IP-10,SCYB10,INP10,crg-2,chemokine (C-X-C motif) ligand 10,gIP-10 |
Amino Acid | IPLARTVRCN CIHIDDGPVR MRAIGKLEII PASLSCPRVE IIATMKKNDE QRCLNPESKT IKNLMKAFSQ KRSKRAP |
Construction | 22-98 aa |
Protein Purity | >97% as determined by SDS-PAGE. |
Molecular Weight | 8.7 kDa as predicted |
Endotoxin | < 1.0 EU/μg of the protein as determined by the LAL method. |
Formulation | 0.2 μm filtered 2×PBS, pH 7.4, lyophilized. |
Reconstitution | A hardcopy of COA with reconstitution instructions is sent along with the products. Please refer to it for detailed information. |
Stability & Storage | Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
Shipping | In general, Lyophilized powders are shipping with blue ice. |
Research Background | (C-X-C motif) ligand (CXCL)10 (CXCL10) belongs to the ELR(-) CXC subfamily chemokine. CXCL10/IP-10 exerts its function through binding to chemokine (C-X-C motif) receptor 3 (CXCR3), a seven trans-membrane receptor coupled to G proteins. CXCL10/IP-10 and its receptor, CXCR3, appear to contribute to the pathogenesis of many autoimmune diseases, organ specific (such as type 1 diabetes, autoimmune thyroiditis, Graves' disease and ophthalmopathy), or systemic (such as rheumatoid arthritis, psoriatic arthritis, systemic lupus erythematosus, mixed cryoglobulinemia, Sjögren syndrome, or systemic sclerosis). CXCL10/IP-10 is secreted by several cell types including endothelial cells, fibroblasts, keratinocytes, thyrocytes, preadipocytes, etc. Determination of high level of CXCL10/IP-10 in peripheral fluids is therefore a marker of host immune response. |
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