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EpCAM/TROP1 Protein, Human, Recombinant (His), Biotinylated

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EpCAM/TROP1 Protein, Human, Recombinant (His), Biotinylated

Catalog No. TMPY-04953

EpCAM/TROP1 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 29 kDa and the accession number is P16422.

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Pack Size	Price	Availability	Quantity
20 μg	$306	7-10 days
100 μg	$726	7-10 days

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Biological Description

Biological Information	Testing in progress
Description	EpCAM/TROP1 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 29 kDa and the accession number is P16422.
Species	Human
Expression System	HEK293 Cells
Tag	C-His
Accession Number	P16422
Synonyms	M4S1,EGP-2,DIAR5,TROP1,TROP-1,HNPCC8,epithelial cell adhesion molecule,EGP40,KS1/4,ESA,EGP314,TACSTD1,KSA,MIC18,MK-1
Construction	The extracellular domain (Met1-Lys265) of Human EpCAM (NP_002345.1) was fused with a polyhistidine tag at the C-terminus. The purified protein was biotinylated in vitro.
Protein Purity	> 95% as determined by SDS-PAGE.
Molecular Weight	29 kDa (predicted)
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, Lyophilized powders are shipping with blue ice.
Research Background	Epithelial Cell Adhesion Molecule (EpCAM), also known as GA733-2 antigen, is a type I transmembrane glycoprotein composed of an extracellular domain with two EGF-Like repeats and a cystenin-rich region, a transmembrane domain and a cytoplasmic domain. It modulates cell adhesion and proliferation. Its overexpression has been detected in many epithelial tumours and has been associated with high stage, high grade and a worse survival in some tumour types. EpCAM has been shown to function as a calcium-independent homophilic cell adhesion molecule that does not exhibit any obvious relationship to the four known cell adhesion molecule superfamilies. However, recent insights have revealed that EpCAM participates in not only cell adhesion, but also in proliferation, migration and differentiation of cells. In addition, recent study revealed that EpCAM is the Wnt-beta-catenin signaling target gene and may be used to facilitate prognosis. It has oncogenic potential and is activated by release of its intracellular domain, which can signal into the cell nucleus by engagement of elements of the wnt pathway.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy