GDF-15 Protein, Rat, Recombinant (His)

Catalog No. TMPK-01243

Growth Differentiation Factor 15 (GDF15), also known as NSAID activated gene-1 (NAG-1), is associated with a large number of biological processes and diseases, including cancer and obesity. GDF15 is synthesized as pro-GDF15, is dimerized, and is cleaved and secreted into the circulation as a mature dimer GDF15. GDF-15 Protein, Rat, Recombinant (His) is expressed in E. coli expression system with N-His tag. The predicted molecular weight is 13.68 kDa and the accession number is Q9Z0J6.

GDF-15 Protein, Rat, Recombinant (His)

Catalog No. TMPK-01243

Pack Size	Price	Availability
100 μg	$698	In Stock
500 μg	$2,800	7-10 days
1 mg	$4,650	7-10 days

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Product Information

Biological Activity	1. Immobilized Rat GDF-15, His Tag at 5 μg/mL (100 μL/well) on the plate. Dose response curve for Human GFRAL, hFc Tag with the EC50 of 8.0 ng/mL determined by ELISA._x000D_ 2. Immobilized Rat GDF15, His Tag at 5 μg/mL (100 μL/well) on the plate. Dose response curve for Biotinylated Mouse GFRAL, His Tag with the EC50 of 0.95 μg/mL determined by ELISA.
Description	Growth Differentiation Factor 15 (GDF15), also known as NSAID activated gene-1 (NAG-1), is associated with a large number of biological processes and diseases, including cancer and obesity. GDF15 is synthesized as pro-GDF15, is dimerized, and is cleaved and secreted into the circulation as a mature dimer GDF15. GDF-15 Protein, Rat, Recombinant (His) is expressed in E. coli expression system with N-His tag. The predicted molecular weight is 13.68 kDa and the accession number is Q9Z0J6.
Species	Rat
Expression System	E. coli
Tag	N-His
Accession Number	Q9Z0J6
Synonyms	RG-1,PTGF-β,PTGFBPTGF-β,PTGFBPTGF-beta,PTGF-beta,PTGFB,Placental TGF-β,Placental TGF-beta,PLAB,PDF,NAG-1,MIC-1,MIC1,GDF-15,GDF15
Construction	Ser189-Ala303
Protein Purity	> 95% as determined by Tris-Bis PAGE
Molecular Weight	13.68 kDa (predicted). The protein migrates to 15-17 kDa based on Tris-Bis PAGE result.
Endotoxin	< 1 EU/μg by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing 50 mM HAc (pH 2.9). Typically, 8% trehalose is incorporated as a protective agent before lyophilization.
Reconstitution	Reconstitute the lyophilized protein in 50mM HAc (pH 2.9). The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
Stability & Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, Lyophilized powders are shipping with blue ice.
Research Background	Growth Differentiation Factor 15 (GDF15), also known as NSAID activated gene-1 (NAG-1), is associated with a large number of biological processes and diseases, including cancer and obesity. GDF15 is synthesized as pro-GDF15, is dimerized, and is cleaved and secreted into the circulation as a mature dimer GDF15.