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IL12RB1 Protein, Human, Recombinant (aa 1-540, hFc)

Catalog No. TMPY-07074

IL12RB1 Protein, Human, Recombinant (aa 1-540, hFc) is expressed in HEK293 Cells. The accession number is P42701-1.

IL12RB1 Protein, Human, Recombinant (aa 1-540, hFc)

IL12RB1 Protein, Human, Recombinant (aa 1-540, hFc)

Catalog No. TMPY-07074
IL12RB1 Protein, Human, Recombinant (aa 1-540, hFc) is expressed in HEK293 Cells. The accession number is P42701-1.
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100 μg $588Backorder
1 mg $3,880Backorder
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Product Information

Biological Activity
Immobilized Recombinant Human IL-23 (IL23A & IL12B Heterodimer) Protein (His Tag) at 2 μg/mL (100 μL/well) can bind IL12RB1 Protein, Human, Recombinant (aa 1-540, hFc) (Cat#TMPY-07074), the EC50 is 15-45 ng/mL.
Description
IL12RB1 Protein, Human, Recombinant (aa 1-540, hFc) is expressed in HEK293 Cells. The accession number is P42701-1.
Species
Human
Expression System
HEK293 Cells
TagC-hFc
Accession NumberP42701-1
Synonyms
IMD30,IL-12R-BETA1,IL12RB,IL12R,CD212
Construction
A DNA sequence encoding the Human IL12RB1 (NP_005526.1) (Met1-Glu540) was expressed with the Fc region of human IgG1 at the C-terminus.
Protein Purity
≥ 90% as determined by SDS-PAGE.
Molecular Weight84.13 kDa (predicted); 98.4 kDa (reducing contition, due to glycosylation)
Endotoxin< 1.0 EU per μg of the protein as determined by the LAL method
FormulationLyophilized from sterile PBS, pH 7.4. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution
Please refer to the lot-specific COA.
Stability & Storage
It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
ShippingIn general, Lyophilized powders are shipping with blue ice.
Research Background
Interleukin 12 receptor, beta 1 is also known as IL-12 receptor beta component, IL-12R subunit beta-1, and CD212 antigen (CD212). IL12RB1(CD212) is a subunit of the interleukin 12 receptor. IL12RB1(CD212) is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukin 12 (IL12) with a low affinity and is thought to be a part of the IL12 receptor complex. IL12RB1(CD212) forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of IL12RB1 and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The lack of expression of this gene was found to result in the immunodeficiency of patients with severe mycobacterial and Salmonella infections. IL12RB1(CD212) Functions as an interleukin receptor that binds interleukin-12 with low affinity and is involved in IL12 transduction. It is associated with IL12RB2 it forms a functional, high-affinity receptor for IL12. IL12RB1(CD212) associates also with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade.

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