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Recombinant ProteinsEnzymesTransferases,EC 2MST1 Protein, Human, Recombinant (His)
TOPBiological Description

MST1 Protein, Human, Recombinant (His)

MST1 Protein, Human, Recombinant (His)
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MST1 Protein, Human, Recombinant (His)

Catalog No. TMPY-04398
Dysregulation of MST1/STK4, a key kinase component of the Hippo-YAP pathway, is linked to the etiology of many cancers with poor prognosis. STK4/Hippo pathway may have important therapeutic implications for cancer. The tumor suppressor serine/threonine-protein kinase 4 (STK4) differentially regulates TLR3/4/9-mediated inflammatory responses in macrophages and thereby is protective against chronic inflammation-associated Hepatocellular carcinoma (HCC). STK4 has potential as a diagnostic biomarker and therapeutic target for inflammation-induced HCC.
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Pack SizePriceAvailabilityQuantity
50 μg$4987-10 days
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Biological Description

Biological Information
The specific activity was determined to be ＞150 nmol/min/mg using MBP as substrate.
Description
Dysregulation of MST1/STK4, a key kinase component of the Hippo-YAP pathway, is linked to the etiology of many cancers with poor prognosis. STK4/Hippo pathway may have important therapeutic implications for cancer. The tumor suppressor serine/threonine-protein kinase 4 (STK4) differentially regulates TLR3/4/9-mediated inflammatory responses in macrophages and thereby is protective against chronic inflammation-associated Hepatocellular carcinoma (HCC). STK4 has potential as a diagnostic biomarker and therapeutic target for inflammation-induced HCC.
Species
Human
Expression System
Baculovirus Insect Cells
TagN-His
Accession NumberQ13043-1
Synonyms
serine/threonine kinase 4,KRS2,MST1,TIIAC,YSK3
Construction
The Human STK4 isoform 1 (Q13043-1) (Glu 2-Phe 487) was expressed, with a polyhistidine tag at the N-terminus.
Protein Purity
> 92 % as determined by SDS-PAGE.
Molecular Weight58 kDa (predicted)
Endotoxin< 1.0 EU/μg of the protein as determined by the LAL method.
FormulationSupplied as sterile 20 mM Tris, 500 mM NaCl, pH 7.4, 10% glycerol.
Reconstitution
A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage
It is recommended to store the product under sterile conditions at -20°C to -80°C. Samples are stable for up to 12 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
ShippingShipping with blue ice.
Research Background
Dysregulation of MST1/STK4, a key kinase component of the Hippo-YAP pathway, is linked to the etiology of many cancers with poor prognosis. STK4/Hippo pathway may have important therapeutic implications for cancer. The tumor suppressor serine/threonine-protein kinase 4 (STK4) differentially regulates TLR3/4/9-mediated inflammatory responses in macrophages and thereby is protective against chronic inflammation-associated Hepatocellular carcinoma (HCC). STK4 has potential as a diagnostic biomarker and therapeutic target for inflammation-induced HCC.

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Keywords

KRS 2MST 1MST-1KRS-2YSK 3YSK-3
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