N Cadherin Protein, Mouse, Recombinant

Catalog No. TMPY-03703

N Cadherin Protein, Mouse, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 29 kDa and the accession number is P15116.

N Cadherin Protein, Mouse, Recombinant

Catalog No. TMPY-03703

N Cadherin Protein, Mouse, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 29 kDa and the accession number is P15116.

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100 μg	$600	7-10 days

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Product Information

Biological Activity	Activity testing is in progress. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
Description	N Cadherin Protein, Mouse, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 29 kDa and the accession number is P15116.
Species	Mouse
Expression System	HEK293 Cells
Tag	Tag Free
Accession Number	P15116
Synonyms	N-cadherin,Ncad,CDHN,cadherin 2, type 1, N-cadherin (neuronal)
Construction	A DNA sequence encoding the mouse CDH2 (P15116) (Met1-Ala724) was fused with six amino acids (LEVLFQ) at the C-terminus was expressed and purified. Predicted N terminal: Ser 26
Protein Purity	> 80 % as determined by SDS-PAGE
Molecular Weight	29 kDa (predicted); 91 and 114 kDa (reducing condition, due to glycosylation)
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, Lyophilized powders are shipping with blue ice.
Research Background	Cadherins are calcium-dependent cell adhesion proteins, and they preferentially interact with themselves in a homophilic manner in connecting cells. Cadherin 2 (CDH2), also known as N-Cadherin (neuronal) (NCAD), is a single-pass transmembrane protein and a cadherin containing 5 cadherin domains. N-Cadherin displays a ubiquitous expression pattern but with different expression levels between endocrine cell types. CDH2 (NCAD) has been shown to play an essential role in normal neuronal development, which is implicated in an array of processes including neuronal differentiation and migration, and axon growth and fasciculation. In addition, N-Cadherin expression was upregulated in human HSC during activation in culture, and function or expression blocking of N-Cadherin promoted apoptosis. During apoptosis, N-Cadherin was cleaved into 20-100 kDa fragments. It may provide a novel target for therapies that are directed toward intimal proliferative disorders, including restenosis and vascular bypass graft failure. N-Cadherin is associated with tumor aggressiveness and metastatic potential and may contribute to tumor progression.