Activity testing is in progress. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.

PSG1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 70.2 kDa and the accession number is P11464-1.

Human

HEK293 Cells

SP1,PS-β-G-1,PS-β-C/D,PSGIIA,PSGGA,PSG95,PSBG-1,PSBG1,PS-beta-G-1,PS-beta-C/D,pregnancy specific β-1-glycoprotein 1,pregnancy specific beta-1-glycoprotein 1,PBG1,FL-NCA-1/2,DHFRP2,CD66f,B1G1

A DNA sequence encoding the human PSG1 (NP_001171754.1) (Met1-Pro419) was expressed with the Fc region of human IgG1 at the C-terminus. Predicted N terminal: Gln 35

> 85 % as determined by SDS-PAGE.

A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.

It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

Pregnancy-specific glycoproteins (PSGs) are a family of Ig-like proteins secreted by specialized placental cells. The PSG1 structure is composed of a single Ig variable region-like N-terminal domain and three Ig constant region-like domains termed A1, A2, and B2. Members of the human and murine PSG family have been shown to induce anti-inflammatory cytokines from monocytes and macrophages and to stimulate angiogenesis. Two distinct domains of PSG1 are involved in the regulation of TGF-beta1 and provide a mechanistic framework for how PSGs modulate the immunoregulatory environment at the maternal-fetal interface for successful pregnancy outcome.