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ST2/IL-1 RL1 Protein, Mouse, Recombinant (hFc)

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ST2/IL-1 RL1 Protein, Mouse, Recombinant (hFc)

Catalog No. TMPY-03493

ST2/IL-1 RL1 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 61.8 kDa and the accession number is P14719-1.

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Pack Size	Price	Availability	Quantity
100 μg	$600	7-10 days

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Biological Description

Biological Information	1.Measured by its binding ability in a functional ELISA. 2. Immobilized canine IL33 at 10μg/mL (100μL/well) can bind mouse IL1RL1-Fc, the EC50 of mouse IL1RL1-Fc is 0.05-0.3 μg/mL.
Description	ST2/IL-1 RL1 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 61.8 kDa and the accession number is P14719-1.
Species	Mouse
Expression System	HEK293 Cells
Tag	C-hFc
Accession Number	P14719-1
Synonyms	St2,ST2L,T1/ST2,interleukin 1 receptor-like 1,DER4,St2-rs1,Fit-1,Ly84,T1
Construction	The Mouse ST2 (NP_001020773.1) (Met1-Arg332) was expressed with the Fc region of Human IgG1 at the C-terminus.
Protein Purity	> 90 % as determined by SDS-PAGE
Molecular Weight	61.8 kDa (predicted)
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, Lyophilized powders are shipping with blue ice.
Research Background	IL-1 receptor–like 1 (IL1RL1) is a membrane receptor involved in TH2 inflammatory responses and eosinophilia. It has previously been described that levels of the interleukin-1 like 1 (IL1RL1) protein can be used to diagnose cardiovascular disease and determine the prognosis for a patient with cardiovascular disease. The ligand for IL1RL1 has been described and named IL-33. Mutants in IL1RL1 have been associated with blood eosinophil counts in a genome-wide association study and with asthma in family-based and case-control studies. As an important mediator involved in many immune and inflammatory responses, this cytokine has been implicated as a regulator of both the development and effector phases of type 2 helper T cell responses, and as a negative feedback modulator of macrophage proinflammatory function. IL33 is a specific ligand of ST2L and induces the production of Th2 cytokines.