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(±)5-HEPE

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Catalog No. T36603Cas No. 83952-40-3

(±)5-HEPE is produced by non-enzymatic oxidation of EPA and contains equal amounts of 5(S)-HEPE and 5(R)-HEPE. The biological activity of (±)5-HEPE is likely mediated by one of the individual isomers, most commonly the 5(S) isomer in mammalian systems. EPA can be metabolized to 5-HEPE in human and bovine neutrophils, and human eosinophils, which is further metabolized to 5-oxoEPE and LTB5. The 5-series metabolites of EPA, including 5-HEPE, 5-oxoEPE, and LTB5, have significantly decreased biological effects compared to the arachidonic acid-derived metabolites.

(±)5-HEPE
Other Forms of (±)5-HEPE:

(±)5-HEPE

😃Good
Catalog No. T36603Cas No. 83952-40-3
(±)5-HEPE is produced by non-enzymatic oxidation of EPA and contains equal amounts of 5(S)-HEPE and 5(R)-HEPE. The biological activity of (±)5-HEPE is likely mediated by one of the individual isomers, most commonly the 5(S) isomer in mammalian systems. EPA can be metabolized to 5-HEPE in human and bovine neutrophils, and human eosinophils, which is further metabolized to 5-oxoEPE and LTB5. The 5-series metabolites of EPA, including 5-HEPE, 5-oxoEPE, and LTB5, have significantly decreased biological effects compared to the arachidonic acid-derived metabolites.
Pack SizePriceAvailabilityQuantity
25 μgInquiry35 days
50 μgInquiry35 days
100 μgInquiry35 days
250 μgInquiry35 days
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Product Introduction

Bioactivity
Description
(±)5-HEPE is produced by non-enzymatic oxidation of EPA and contains equal amounts of 5(S)-HEPE and 5(R)-HEPE. The biological activity of (±)5-HEPE is likely mediated by one of the individual isomers, most commonly the 5(S) isomer in mammalian systems. EPA can be metabolized to 5-HEPE in human and bovine neutrophils, and human eosinophils, which is further metabolized to 5-oxoEPE and LTB5. The 5-series metabolites of EPA, including 5-HEPE, 5-oxoEPE, and LTB5, have significantly decreased biological effects compared to the arachidonic acid-derived metabolites.
Chemical Properties
Molecular Weight318.457
FormulaC20H30O3
Cas No.83952-40-3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
PBS (pH 7.2): 0.8 mg/mL (2.51 mM), Sonication is recommended.
DMSO: Miscible
0.1 M Na2CO3: 2 mg/mL (6.28 mM), Sonication is recommended.
Ethanol: Miscible
DMF: Miscible
Solution Preparation Table
PBS (pH 7.2)/0.1 M Na2CO3
1mg5mg10mg50mg
1 mM3.1401 mL15.7007 mL31.4014 mL157.0071 mL
0.1 M Na2CO3
1mg5mg10mg50mg
5 mM0.6280 mL3.1401 mL6.2803 mL31.4014 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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Keywords

(±)5 HEPE(±)5HEPE5-HEPE
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