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12(S)-HEPE

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Catalog No. T37967Cas No. 116180-17-7

12(S)-HEPE is a monohydroxy fatty acid synthesized from EPA by the action of 12-LO. Unstimulated neutrophils metabolize 12(S)-HEPE to 12(S),20-diHEPE, while stimulated neutrophils produce 5(S),12(S)-HEPE via the 5-lipoxygenase pathway. The competitive action of 12(S)-HEPE with arachidonic acid as a substrate for 5-LO in leukotriene formation may underlie the anti-inflammatory potential of ω-3 fatty acids.

12(S)-HEPE
Other Forms of 12(S)-HEPE:

12(S)-HEPE

😃Good
Catalog No. T37967Cas No. 116180-17-7
12(S)-HEPE is a monohydroxy fatty acid synthesized from EPA by the action of 12-LO. Unstimulated neutrophils metabolize 12(S)-HEPE to 12(S),20-diHEPE, while stimulated neutrophils produce 5(S),12(S)-HEPE via the 5-lipoxygenase pathway. The competitive action of 12(S)-HEPE with arachidonic acid as a substrate for 5-LO in leukotriene formation may underlie the anti-inflammatory potential of ω-3 fatty acids.
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Product Introduction

Bioactivity
Description
12(S)-HEPE is a monohydroxy fatty acid synthesized from EPA by the action of 12-LO. Unstimulated neutrophils metabolize 12(S)-HEPE to 12(S),20-diHEPE, while stimulated neutrophils produce 5(S),12(S)-HEPE via the 5-lipoxygenase pathway. The competitive action of 12(S)-HEPE with arachidonic acid as a substrate for 5-LO in leukotriene formation may underlie the anti-inflammatory potential of ω-3 fatty acids.
Chemical Properties
Molecular Weight318.45
FormulaC20H30O3
Cas No.116180-17-7
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
0.1 M Na2CO3: 2 mg/mL (6.28 mM), Sonication is recommended.
DMF: Miscible
DMSO: Miscible
PBS (pH 7.2): 0.8 mg/mL (2.51 mM), Sonication is recommended.
Ethanol: Miscible
Solution Preparation Table
PBS (pH 7.2)/0.1 M Na2CO3
1mg5mg10mg50mg
1 mM3.1402 mL15.7011 mL31.4021 mL157.0105 mL
0.1 M Na2CO3
1mg5mg10mg50mg
5 mM0.6280 mL3.1402 mL6.2804 mL31.4021 mL

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Keywords

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