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12(S)-HEPE is a monohydroxy fatty acid synthesized from EPA by the action of 12-LO. Unstimulated neutrophils metabolize 12(S)-HEPE to 12(S),20-diHEPE, while stimulated neutrophils produce 5(S),12(S)-HEPE via the 5-lipoxygenase pathway. The competitive action of 12(S)-HEPE with arachidonic acid as a substrate for 5-LO in leukotriene formation may underlie the anti-inflammatory potential of ω-3 fatty acids.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 μg | $383 | 35 days | |
50 μg | $725 | 35 days | |
100 μg | $1,360 | 35 days |
Description | 12(S)-HEPE is a monohydroxy fatty acid synthesized from EPA by the action of 12-LO. Unstimulated neutrophils metabolize 12(S)-HEPE to 12(S),20-diHEPE, while stimulated neutrophils produce 5(S),12(S)-HEPE via the 5-lipoxygenase pathway. The competitive action of 12(S)-HEPE with arachidonic acid as a substrate for 5-LO in leukotriene formation may underlie the anti-inflammatory potential of ω-3 fatty acids. |
Molecular Weight | 318.45 |
Formula | C20H30O3 |
Cas No. | 116180-17-7 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
Solubility Information | 0.1 M Na2CO3: 2 mg/mL (6.28 mM), Sonication is recommended. DMF: Miscible DMSO: Miscible PBS (pH 7.2): 0.8 mg/mL (2.51 mM), Sonication is recommended. Ethanol: Miscible | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
PBS (pH 7.2)/0.1 M Na2CO3
0.1 M Na2CO3
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