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Pack Size | Price | Availability | Quantity |
---|---|---|---|
2 mg | $163 | 5 days |
Description | (Rac)-5-Hydroxymethyl Tolterodine hydrochloride, also known as (Rac)-Desfesoterodine hydrochloride, is an active metabolite of Tolterodine that functions as a mAChR antagonist. It exhibits significant affinity (K i values) for M1, M2, M3, M4, and M5 receptors, with values of 2.3 nM, 2 nM, 2.5 nM, 2.8 nM, and 2.9 nM, respectively. This compound is commonly employed in research related to overactive bladder conditions. |
In vitro | In vitro, (Rac)-5-Hydroxymethyl Tolterodine (PNU-200577) hydrochloride demonstrates competitive, concentration-dependent inhibition of carbachol-induced contraction in isolated guinea-pig urinary bladder strips, with a binding affinity (K B) of 0.84 nM and a potency of 9.14 (pA2)[2]. |
In vivo | Treatment with (Rac)-5-Hydroxymethyl Tolterodine (5-HMT; 0.88 μmol/kg; i.v.) hydrochloride demonstrates significant binding activity to muscarinic receptors across all tissues, barring the cerebral cortex, and exhibits prolonged activity in the bladder[3]. |
Alias | (Rac)-5-Hydroxymethyl Tolterodine hydrochloride, (Rac)-PNU-200577hydrochloride, (Rac)-Desfesoterodine hydrochloride |
Molecular Weight | 377.95 |
Formula | C22H32ClNO2 |
Cas No. | 250214-40-5 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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