Shopping Cart
- Remove All
Your shopping cart is currently empty
Desfesoterodine
🥰Excellent
Catalog No. T6364Cas No. 207679-81-0
Alias PNU-200577, 5-hydroxymethyl Tolterodine, 5-HMT, 5-HM, (R)-5-Hydroxymethyl Tolterodine
Desfesoterodine (5-HMT) is a new muscarinic receptor antagonist with Kb of 0.84 nM.
Desfesoterodine
🥰Excellent
Purity: 100%
Catalog No. T6364Alias PNU-200577, 5-hydroxymethyl Tolterodine, 5-HMT, 5-HM, (R)-5-Hydroxymethyl TolterodineCas No. 207679-81-0
Desfesoterodine (5-HMT) is a new muscarinic receptor antagonist with Kb of 0.84 nM.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $60 | In Stock | |
| 5 mg | $147 | In Stock | |
| 10 mg | $228 | In Stock | |
| 25 mg | $392 | In Stock | |
| 50 mg | $578 | In Stock | |
| 100 mg | $833 | In Stock | |
| 500 mg | $1,690 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $162 | In Stock |
Bulk & Custom
Add to Cart
Questions
View MoreInhibitors Related to "Desfesoterodine"
Urethane
Cited
Ethylurethane, Ethyl carbamate, Carbamic acid ethyl ester
T005151-79-6
Urethane (Ethylurethane) was an antineoplastic agent .Now is used for other medicinal purposes.
- $29
Size
QTY
CitedAdiphenine hydrochloride
Spasnil, Sentiv, Patrovina, Adiphenine HCl
T007250-42-0
Adiphenine hydrochloride (Patrovina), a nicotinic receptor inhibitor, can be used as an antispasmodic drug.
- $39
Size
QTY
D-Menthol
Menthol, (+)-MENTHOL
TN154415356-60-2
D-Menthol ((+)-MENTHOL) is a common compound in pharmaceutical and commercial products and a popular additive to cigarettes, it attenuates α±7 mediated Ca 2+ transients in the cell body and neurite, suggests that menthol inhibits α±7-nACh receptors in a noncompetitive manner.
- $39
Size
QTY
Ribavirin Cited
Tribavirin, RTCA, NSC-163039, ICN-1229
T068436791-04-5
Ribavirin (Tribavirin) is a synthetic nucleoside analog of ribofuranose with activity against hepatitis C virus and other RNA viruses.
- $39
Size
QTY
CitedCholine chloride
Hepacholine, Biocoline, Biocolina
T103967-48-1
Choline chloride (Biocoline) is a basic constituent of lecithin that is found in many plants and animal organs. It is important as a precursor of acetylcholine, as a methyl donor in various metabolic processes, and in lipid metabolism.
- $33
Size
QTY
Propoxur
Propoxure, Baygon, Aprocarb
T0976114-26-1
Propoxur (Propoxure) is an insecticide used to control cockroaches, flies, mosquitoes, and lawn and turf insects. Acute (short-term) exposure of humans to propoxur by ingestion leads to cholinesterase inhibition of red blood cells, with mild cholinergic symptoms including blurred vision, nausea, vomiting, sweating, and tachycardia; however, the effects are transient. Chronic (long-term) inhalation exposure has resulted in depressed cholinesterase levels, headaches, vomiting, and nausea in humans. Chronic ingestion studies in animals have reported depressed cholinesterase levels, depressed body weight, effects to the liver and bladder, and a slight increase in neuropathy. No information is available on the reproductive, developmental, or carcinogenic effects of propoxur in humans. Mixed results are available from cancer studies of propoxur in animals. EPA has not classified propoxur for carcinogenicity.
- $29
Size
QTY
Nanofin
Naniopinum, Lupetidine, Lupetidin, 2,6-Lupetidine, 2,6-Dimethylpiperidine
T1007504-03-0
Nanofin (Lupetidine) is a neuropathic blocker, with antihypertensive effect.
- $42
Size
QTY
Clozapine N-Oxide
Cited
T449434233-69-7
Clozapine N-oxide is the major metabolite of Clozapine and is blood-brain barrier permeable. Clozapine N-oxide is an agonist of DREADDs and activates the DREADD receptors hM3Dq and hM4Di. Clozapine N-oxide is also a dopamine antagonist and selective muscarinic M4 receptor agonist.
- $30
Size
QTY
CitedPilocarpine nitrate Cited
Pilofrin, Pilagan
T1231148-72-1
Pilocarpine nitrate (Pilagan) is a slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glaucoma.
- $41
Size
QTY
CitedForskolin Cited
FSK, Colforsin, Coleonol
T293966575-29-9
Forskolin (Coleonol) is a natural product, an adenylate cyclase activator (EC50=0.5 μM). Forskolin increases cAMP levels, activates PXR and FXR, and induces autophagy. Forskolin produces positive inotropic effects in the heart, and has platelet anticoagulant and antihypertensive effects.
- $36
Size
QTY
CitedAmitriptyline hydrochloride
Tryptizol, Domical, Annoyltin, Amitriptyline HCl
T0678549-18-8
Amitriptyline hydrochloride (Annoyltin) is the hydrochloride salt of the tricyclic dibenzocycloheptadiene amitriptyline with antidepressant and antinociceptive activities.
5-HT ReceptorAChRAdrenergic ReceptorHistamine ReceptorNorepinephrineSerotonin TransporterSigma receptorSodium ChannelTrk receptor
- $45
Size
QTY
Pilocarpine Hydrochloride Cited
Pilocarpine HCl, NSC 5746 HCl, (+)-Pilocarpine hydrochloride
T080454-71-7
Pilocarpine Hydrochloride (NSC 5746 HCl) , a nonselective muscarinic acetylcholine receptor agonist, is utilized to produce an experimental model of epilepsy.
- $54
Size
QTY
CitedSelect Batch
Purity:100%
Contact us for more batch information
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Desfesoterodine (5-HMT) is a new muscarinic receptor antagonist with Kb of 0.84 nM. |
| Targets&IC50 | mAChR:0.84 nM(Kb) |
| In vitro | Desfesoterodine is a major pharmacologically active metabolite of tolterodine. Desfesoterodine produces a competitive and concentration-dependent inhibition of carbachol-induced contraction of guinea-pig isolated urinary bladder strips. Desfesoterodine antagotizes muscarinic receptors with a pA2 of 9.1. Desfesoterodine causes a concentration-dependent inhibition of (-)3 H-QNB binding in homogenates of guinea-pig urinary bladder, parotid gland, heart and cerebral cortex. [1] Desfesoterodine has a similar pharmacological profile with tolterodine. [2] Intravenous infusion of Desfesoterodine produces a dose-dependent inhibition of the intravesical volume-induced urinary bladder contraction measured as the micturition pressure. [3] |
| In vivo | Desfesoterodine is significantly more potent at inhibiting acetylcholine-induced urinary bladder contraction than electrically induced salivation in the anaesthetised cat (ID50 15 and 40 nmol/kg, respectively. Desfesoterodine is three times more potent at the urinary bladder compared to the salivary gland. [1] |
| Alias | PNU-200577, 5-hydroxymethyl Tolterodine, 5-HMT, 5-HM, (R)-5-Hydroxymethyl Tolterodine |
| Molecular Weight | 341.49 |
| Formula | C22H31NO2 |
| Cas No. | 207679-81-0 |
| Smiles | CC(C)N(CC[C@H](c1ccccc1)c1cc(CO)ccc1O)C(C)C |
| Relative Density. | 1.060 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | Ethanol: 63 mg/mL (184.5 mM) DMSO: 65 mg/mL (190.34 mM), Sonication is recommended.  H2O: < 1 mg/mL (insoluble or slightly soluble) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
Ethanol/DMSO
| ||||||||||||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
Preview
Related Tags: buy Desfesoterodine | purchase Desfesoterodine | Desfesoterodine cost | order Desfesoterodine | Desfesoterodine chemical structure | Desfesoterodine in vivo | Desfesoterodine in vitro | Desfesoterodine formula | Desfesoterodine molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.