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(Rac)-Indoximod

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Catalog No. T60266Cas No. 26988-72-7

(Rac)-Indoximod (1-Methyl-DL-tryptophan) is a potent inhibitor of indoleamine 2,3-dioxygenase (IDO). Combined treatment with IFN-γ and (Rac)-Indoximod significantly suppresses the activity of α-SMA-expressing human cardiac myofibroblasts (hCMs) and promotes apoptosis by up-regulating the genes IRF-1, Fas, and FasL, effectively improving cardiac fibrosis[1].

(Rac)-Indoximod
Other Forms of (Rac)-Indoximod:

(Rac)-Indoximod

😃Good
Catalog No. T60266Cas No. 26988-72-7
(Rac)-Indoximod (1-Methyl-DL-tryptophan) is a potent inhibitor of indoleamine 2,3-dioxygenase (IDO). Combined treatment with IFN-γ and (Rac)-Indoximod significantly suppresses the activity of α-SMA-expressing human cardiac myofibroblasts (hCMs) and promotes apoptosis by up-regulating the genes IRF-1, Fas, and FasL, effectively improving cardiac fibrosis[1].
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25 mgInquiry6-8 weeks
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Product Introduction

Bioactivity
Description
(Rac)-Indoximod (1-Methyl-DL-tryptophan) is a potent inhibitor of indoleamine 2,3-dioxygenase (IDO). Combined treatment with IFN-γ and (Rac)-Indoximod significantly suppresses the activity of α-SMA-expressing human cardiac myofibroblasts (hCMs) and promotes apoptosis by up-regulating the genes IRF-1, Fas, and FasL, effectively improving cardiac fibrosis[1].
In vitro
(Rac)-Indoximod (1-Methyl-DL-tryptophan; 0.5 mM; 3 days) mitigates the effects of tryptophan depletion, partially countering IFN-γ-induced growth suppression in human cardiac myofibroblasts (hCMs), but ultimately leads to cell death regardless of tryptophan levels, as shown by a Cell Viability Assay where viability declined notably by the third day.
Chemical Properties
Molecular Weight218.25
FormulaC12H14N2O2
Cas No.26988-72-7
Storage & Solubility Information
StorageShipping with blue ice.

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