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(S)-ML753286

Catalog No. T10490Cas No. 1699720-85-8

(S)-ML753286 is a breast cancer resistance protein (BCRP) inhibitor (IC50: 0.6 μM on BCRP efflux transporter).

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Pack Size	Price	Availability
5 mg	$523	6-8 weeks
25 mg	$1,520	6-8 weeks
50 mg	$1,980	6-8 weeks
100 mg	$2,500	6-8 weeks
1 mL x 10 mM (in DMSO)	$514	6-8 weeks

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Product Introduction

Bioactivity

Description	(S)-ML753286 is a breast cancer resistance protein (BCRP) inhibitor (IC50: 0.6 μM on BCRP efflux transporter).
In vivo	(S)-ML753286 (Compound A) shows the potency and a potent pharmacokinetic (PK) profile in rats (lower clearance [1.54 L/h/kg] and higher bioavailability [123%]).

Chemical Properties

Molecular Weight	355.43
Formula	C20H25N3O3
Cas No.	1699720-85-8

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (140.67 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8135 mL	14.0675 mL	28.1349 mL	140.6747 mL
5 mM	0.5627 mL	2.8135 mL	5.6270 mL	28.1349 mL
10 mM	0.2813 mL	1.4067 mL	2.8135 mL	14.0675 mL
20 mM	0.1407 mL	0.7034 mL	1.4067 mL	7.0337 mL
50 mM	0.0563 mL	0.2813 mL	0.5627 mL	2.8135 mL
100 mM	0.0281 mL	0.1407 mL	0.2813 mL	1.4067 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc