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(S, R, S)-AHPC-C8-NH2 (VH032-C8-NH2) is an E3 ligase ligand-linker conjugate. This compound comprises the VH032-based VHL ligand and a linker, specifically designed for AKT PROTAC degrader applications.
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50 mg | Inquiry | Backorder | |
100 mg | Inquiry | Backorder |
Description | (S, R, S)-AHPC-C8-NH2 (VH032-C8-NH2) is an E3 ligase ligand-linker conjugate. This compound comprises the VH032-based VHL ligand and a linker, specifically designed for AKT PROTAC degrader applications. |
In vitro | PROTACs, or proteolysis-targeting chimeras, are composed of two distinct ligands joined by a linker. One of these ligands binds to a specific protein target, while the other binds to an E3 ubiquitin ligase. When the PROTAC binds to both the target protein and the E3 ligase, it triggers the ubiquitin-proteasome system within cells to degrade the target protein, thereby providing a mechanism for targeted protein degradation. |
Alias | VH032-C8-NH2, (S,R,S)-AHPC-C8-NH2 |
Molecular Weight | 585.81 |
Formula | C31H47N5O4S |
Cas No. | 2341796-79-8 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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