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(Z)-4EGI-1

Catalog No. T37099Cas No. 901787-88-0

(Z)-4EGI-1, the Z-isomer of 4EGI-1, serves as an inhibitor of both the eIF4E/eIF4G interaction and translation initiation. It effectively binds to eIF4E, exhibiting an IC50 of 43.5 μM and a Kd value of 8.74 μM. Notably, (Z)-4EGI-1 possesses anticancer activity[1][2].

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Pack Size	Price	Availability
2 mg	$119	5 days
5 mg	$198	5 days
10 mg	$376	5 days
50 mg	$789	6-8 weeks
100 mg	$1,190	6-8 weeks
1 mL x 10 mM (in DMSO)	$226	5 days

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Product Introduction

Bioactivity

Description

Chemical Properties

Molecular Weight	451.28
Formula	C18H12Cl2N4O4S
Cas No.	901787-88-0

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (110.80 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2159 mL	11.0796 mL	22.1592 mL	110.7960 mL
5 mM	0.4432 mL	2.2159 mL	4.4318 mL	22.1592 mL
10 mM	0.2216 mL	1.1080 mL	2.2159 mL	11.0796 mL
20 mM	0.1108 mL	0.5540 mL	1.1080 mL	5.5398 mL
50 mM	0.0443 mL	0.2216 mL	0.4432 mL	2.2159 mL
100 mM	0.0222 mL	0.1108 mL	0.2216 mL	1.1080 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

(Z)4EGI1(Z) 4EGI 14EGI-1