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(1R,2R)-2-PCCA hydrochloride

🥰Excellent
Catalog No. T13423Cas No. 1609563-71-4
Alias (1R,2R)-2-PCCA(hydrochloride)

(1R,2R)-2-PCCA hydrochloride is a potent, selective, and blood-brain-barrier-crossing GPR88 receptor agonist with an EC50 value of 1140 n in striatal membranes of WT mice; it can be used to study the central nervous system.

(1R,2R)-2-PCCA hydrochloride
Other Forms of (1R,2R)-2-PCCA hydrochloride:

(1R,2R)-2-PCCA hydrochloride

🥰Excellent
Purity: 99.88%
Catalog No. T13423Alias (1R,2R)-2-PCCA(hydrochloride)Cas No. 1609563-71-4
(1R,2R)-2-PCCA hydrochloride is a potent, selective, and blood-brain-barrier-crossing GPR88 receptor agonist with an EC50 value of 1140 n in striatal membranes of WT mice; it can be used to study the central nervous system.
Pack SizePriceAvailabilityQuantity
2 mg$98In Stock
5 mg$147In Stock
10 mg$289In Stock
25 mg$596In Stock
50 mg$787In Stock
100 mg$1,070In Stock
1 mL x 10 mM (in DMSO)$169In Stock
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Purity:99.88%
ee:99.92%
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Product Introduction

Bioactivity
Description
(1R,2R)-2-PCCA hydrochloride is a potent, selective, and blood-brain-barrier-crossing GPR88 receptor agonist with an EC50 value of 1140 n in striatal membranes of WT mice; it can be used to study the central nervous system.
Targets&IC50
GPR88 receptor:3 nM (EC50, cell-free assay), GPR88 receptor:56 nM (EC50, HEK293 cell), GPR88-22F cells:603 nM (EC50)
In vitro
(1R,2R)-2-PCCA hydrochloride (Example 3) is an effective GPR88 receptor agonist with an EC50 of 3 nM in cell-free assay experiments and 603 nM in cellular assays[1]. Through the Gαi-coupled pathway, (1R,2R)-2-PCCA hydrochloride inhibits GPR88-mediated cAMP production, with an EC50 of 56 nM cAMP constructs in HEK293 cells stably expressing human GPR88 receptor and GloSensor-22F[1].
Alias(1R,2R)-2-PCCA(hydrochloride)
Chemical Properties
Molecular Weight528.56
FormulaC30H39Cl2N3O
Cas No.1609563-71-4
SmilesCl.Cl.CCCc1ccc(cc1)-c1ccc(cc1)N(C[C@@H](N)[C@@H](C)CC)C(=O)[C@@H]1C[C@H]1c1ccccn1
Relative Density.no data available
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 20 mg/mL (37.84 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.8919 mL9.4597 mL18.9193 mL94.5966 mL
5 mM0.3784 mL1.8919 mL3.7839 mL18.9193 mL
10 mM0.1892 mL0.9460 mL1.8919 mL9.4597 mL
20 mM0.0946 mL0.4730 mL0.9460 mL4.7298 mL

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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Keywords

2-PCCA(hydrochloride)2-PCCA Hydrochloride(1R,2R)2PCCA hydrochloride(1R,2R) 2 PCCA hydrochloride
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