(R)-Nepicastat HCl

(R)-Nepicastat HCl (RS-25560-198 HCl), the R-enantiomer of Nepicastat HCl, is a potent and selective inhibitor with IC50 of 25.1 nM and 18.3 nM for bovine and human dopamine-β-hydroxylase, with negligible affinity for twelve other enzymes and thirteen neurotransmitter receptors.

Catalog No. T6356Cas No. 195881-94-8

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(R)-Nepicastat HCl

Catalog No. T6356Cas No. 195881-94-8

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Pack Size	Price	Availability
5 mg	$135	6-8 weeks
10 mg	$229	6-8 weeks
25 mg	$432	6-8 weeks
50 mg	$585	6-8 weeks
100 mg	$855	6-8 weeks
1 mL x 10 mM (in DMSO)	$135	6-8 weeks

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Product Introduction

Bioactivity

Description	(R)-Nepicastat HCl (RS-25560-198 HCl), the R-enantiomer of Nepicastat HCl, is a potent and selective inhibitor with IC50 of 25.1 nM and 18.3 nM for bovine and human dopamine-β-hydroxylase, with negligible affinity for twelve other enzymes and thirteen neurotransmitter receptors.
Targets&IC50	DBH (bovine):25.1 nM, DBH (human):18.3 nM
In vitro	(R)-Nepicastat produces concentration-dependent inhibition of bovine and human dopamine-β-hydroxylase activity in vitro. [1]
In vivo	(R)-Nepicastat (30 mg/kg, p.o.) reduces noradrenaline content, dopamine content and dopamine/noradrenaline ratio in mesenteric artery and left ventricle of spontaneously hypertensive rats (SHRs). [1]
Alias	RS-25560-198 HCl

Chemical Properties

Molecular Weight	331.81
Formula	C₁₄H₁₅F₂N₃S·HCl
Cas No.	195881-94-8

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

H2O: <1 mg/mL

DMSO: 61 mg/mL (183.8 mM)

Ethanol: <1 mg/mL

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0138 mL	15.0689 mL	30.1377 mL	150.6886 mL
5 mM	0.6028 mL	3.0138 mL	6.0275 mL	30.1377 mL
10 mM	0.3014 mL	1.5069 mL	3.0138 mL	15.0689 mL
20 mM	0.1507 mL	0.7534 mL	1.5069 mL	7.5344 mL
50 mM	0.0603 mL	0.3014 mL	0.6028 mL	3.0138 mL
100 mM	0.0301 mL	0.1507 mL	0.3014 mL	1.5069 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc