Shopping Cart
- Remove All
![TargetMol](https://www.targetmol.com/storage/error/oops.webp)
Your shopping cart is currently empty
Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $2,140 | 1-2 weeks | |
50 mg | $2,785 | 1-2 weeks | |
100 mg | $3,520 | 1-2 weeks |
Description | Nepicastat (SYN117) is a selective, potent, and orally active dopamine-beta-hydroxylase inhibitor which can cross the blood-brain barrier (BBB). Nepicastat (SYN117) produces concentration-dependent inhibition of bovine and human dopamine-beta-hydroxylase with IC50s of 8.5 nM and 9 nM [1] [2] [3]. |
In vivo | Nepicastat, administered orally at doses ranging from 3 to 100 mg/kg at 12-hour intervals for three consecutive doses, elicited dose-dependent reductions in noradrenaline levels while increasing dopamine levels and the dopamine/noradrenaline ratio in the mesenteric or renal arteries, left ventricle, and cerebral cortex of 15-16 week-old male spontaneously hypertensive rats (SHRs). |
Molecular Weight | 295.35 |
Formula | C14H15F2N3S |
Cas No. | 173997-05-2 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.