Shopping Cart
- Remove All
Your shopping cart is currently empty
(R)-Nepicastat HCl
😃Good
Catalog No. T6356Cas No. 195881-94-8
Alias RS-25560-198 HCl
(R)-Nepicastat HCl (RS-25560-198 HCl), the R-enantiomer of Nepicastat HCl, is a potent and selective inhibitor with IC50 of 25.1 nM and 18.3 nM for bovine and human dopamine-β-hydroxylase, with negligible affinity for twelve other enzymes and thirteen neurotransmitter receptors.
(R)-Nepicastat HCl
😃Good
Catalog No. T6356Alias RS-25560-198 HClCas No. 195881-94-8
(R)-Nepicastat HCl (RS-25560-198 HCl), the R-enantiomer of Nepicastat HCl, is a potent and selective inhibitor with IC50 of 25.1 nM and 18.3 nM for bovine and human dopamine-β-hydroxylase, with negligible affinity for twelve other enzymes and thirteen neurotransmitter receptors.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $135 | 6-8 weeks | |
| 10 mg | $229 | 6-8 weeks | |
| 25 mg | $432 | 6-8 weeks | |
| 50 mg | $585 | 6-8 weeks | |
| 100 mg | $855 | 6-8 weeks | |
| 1 mL x 10 mM (in DMSO) | $135 | 6-8 weeks |
Bulk & Custom
Add to Cart
Questions
View MoreInhibitors Related to "(R)-Nepicastat HCl"
Casein
T839699000-71-9
Casein is a milk protein with multiple roles in a novel drug delivery system that affects postprandial amino acid delivery in different ways through its intragastric coagulation properties.
- $29
Size
QTY
Ketoconazole
Cited
Xolegel, R-41400, Extina, (±)-Ketoconazol
T067965277-42-1
Ketoconazole (R-41400), a CYP3A4 inhibitor, is an imidazole anti-fungal agent.
- $33
Size
QTY
CitedFenclonine
PCPA, Fenchlonine, DL-4-Chlorophenylalanine, CP-10188, 4-Chloro-DL-phenylalanine
T14477424-00-2
Fenclonine (CP-10188) is a selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin (5-HYDROXYTRYPTAMINE). Fenclonine(CP-10188) acts pharmacologically to deplete endogenous levels of serotonin.
- $30
Size
QTY
p-Fluoro-L-phenylalanine
T412741132-68-9
p-Fluoro-L-phenylalanine is a substrate for tyrosine hydroxylase (TH) that can be used to study the regulation of that enzyme. p-Fluoro-L-phenylalanine binds to the L-leucine specific receptor of Escherichia coli with an KD of 0.26 μM.
- $29
Size
QTY
Tetrahydropapaverine hydrochloride
Tetrahydropapaverine HCl, Tetrahydroalkali hydrochloride, Norlaudanosine HCl
T60046429-04-5
Tetrahydropapaverine hydrochloride (Norlaudanosine HCl) , an analogue of salsolinol and tetrahydropapaveroline, has neurotoxicity on dopamine neurons.
- $38
Size
QTY
Mildronate
Quaterin, Meldonium, Kvaterin
T326876144-81-5
Mildronate (Meldonium) is an inhibitor of biosynthesis of L-carnitine by gamma-butyrobetaine (GBB) hydroxylase and as a competitive inhibitor of renal carnitine reabsorption.
- $42
Size
QTY
Telotristat Etiprate
LX1606 (Hippurate), LX 1606 Hippurate
T60441137608-69-5
Telotristat Etiprate (LX 1606 Hippurate) is an orally bioavailable, tryptophan hydroxylase (TPH) inhibitor with potential antiserotonergic activity.
- $38
Size
QTY
Nepicastat hydrochloride
SYN-117 hydrochloride, RS-25560-197 hydrochloride, Nepicastat HCl, Nepicastat (SYN-117) HCl
T6604170151-24-3
Nepicastat hydrochloride (RS-25560-197 hydrochloride) is an effective and specific inhibitor, which is used for bovine and human dopamine-β-hydroxylase with IC50 of 8.5 nM and 9 nM, respectively.The affinity of Nepicastat for twelve other enzymes and thirteen neurotransmitter receptors is negligible.
- $52
Size
QTY
Diethyl-pythiDC
T151241821370-70-0In house
Diethyl-pythiDC is an collagen prolyl 4-hydroxylase inhibitor.
- $38
Size
QTY
p-Ethynylphenylalanine
4-Ethynyl-L-phenylalanine
T10142278605-15-5In house
p-Ethynylphenylalanine (4-Ethynyl-L-phenylalanine), a selective, effective, and reversible tryptophan hydroxylase (TPH) inhibitor, exhibits competitive inhibition with a Ki of 32.6 μM.
- $34
Size
QTY
Bupicomide
T3061522632-06-0In house
Bupicomide is a dopamine beta hydroxylase inhibitor with antihypertensive and vasodilatory activity that reduces 14C-norepinephrine biosynthesis of 14C-dopamine and can be used to study hypertension.
- $293
Size
QTY
Sapropterin dihydrochloride
Sapropterin Hydrochloride, 6R-Tetrahydro-L-biopterin dihydrochloride, 6R-BH4 dihydrochloride
T711769056-38-8
Sapropterin dihydrochloride (6R-BH4 dihydrochloride) is phenylalanine hydroxylase agonist that is approved for the treatment of BH4 responsive PKU.
- $31
Size
QTY
Contact us for more batch information
Resource Download
Product Introduction
Bioactivity
Chemical Properties
| Description | (R)-Nepicastat HCl (RS-25560-198 HCl), the R-enantiomer of Nepicastat HCl, is a potent and selective inhibitor with IC50 of 25.1 nM and 18.3 nM for bovine and human dopamine-β-hydroxylase, with negligible affinity for twelve other enzymes and thirteen neurotransmitter receptors. |
| Targets&IC50 | DBH (bovine):25.1 nM, DBH (human):18.3 nM |
| In vitro | (R)-Nepicastat produces concentration-dependent inhibition of bovine and human dopamine-β-hydroxylase activity in vitro. [1] |
| In vivo | (R)-Nepicastat (30 mg/kg, p.o.) reduces noradrenaline content, dopamine content and dopamine/noradrenaline ratio in mesenteric artery and left ventricle of spontaneously hypertensive rats (SHRs). [1] |
| Alias | RS-25560-198 HCl |
| Molecular Weight | 331.81 |
| Formula | C14H15F2N3S·HCl |
| Cas No. | 195881-94-8 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | H2O: <1 mg/mL DMSO: 61 mg/mL (183.8 mM) Ethanol: <1 mg/mL | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
| ||||||||||||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: buy (R)-Nepicastat HCl | purchase (R)-Nepicastat HCl | (R)-Nepicastat HCl cost | order (R)-Nepicastat HCl | (R)-Nepicastat HCl chemical structure | (R)-Nepicastat HCl in vivo | (R)-Nepicastat HCl in vitro | (R)-Nepicastat HCl formula | (R)-Nepicastat HCl molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.