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Telotristat Etiprate

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Purity:99.36%

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COA HNMR HPLC

Telotristat Etiprate

Catalog No. T6044Cas No. 1137608-69-5

Telotristat Etiprate (LX 1606 Hippurate) is an orally bioavailable, tryptophan hydroxylase (TPH) inhibitor with potential antiserotonergic activity.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability
2 mg	$38	In Stock
5 mg	$61	In Stock
10 mg	$93	In Stock
25 mg	$153	In Stock
50 mg	$193	In Stock
100 mg	$343	In Stock
500 mg	$822	In Stock
1 mL x 10 mM (in DMSO)	$77	In Stock

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Product Introduction

Bioactivity

Description	Telotristat Etiprate (LX 1606 Hippurate) is an orally bioavailable, tryptophan hydroxylase (TPH) inhibitor with potential antiserotonergic activity.
In vivo	Telotristat Etiprate (300 mg/kg p.o.) significantly reduces 5-HT in the gut and blood, but not brain 5-HT. Telotristat Etiprate (200 mg/kg p.o.) alleviates the severity of trinitrobenzene sulfonic acid (TNBS)-induced colitis with lower expression of some genes encoding inflammation-related cytokines and chemokines in mice. [2]
Alias	LX1606 (Hippurate), LX 1606 Hippurate

Chemical Properties

Molecular Weight	754.15
Formula	C27H26ClF3N6O3·C9H9NO3
Cas No.	1137608-69-5

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 100 mg/mL (132.59 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.3260 mL	6.6300 mL	13.2600 mL	66.2998 mL
5 mM	0.2652 mL	1.3260 mL	2.6520 mL	13.2600 mL
10 mM	0.1326 mL	0.6630 mL	1.3260 mL	6.6300 mL
20 mM	0.0663 mL	0.3315 mL	0.6630 mL	3.3150 mL
50 mM	0.0265 mL	0.1326 mL	0.2652 mL	1.3260 mL
100 mM	0.0133 mL	0.0663 mL	0.1326 mL	0.6630 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc